Principal Scientist

ZipRecruiter; England; On-site; GBP 60,000 - 100,000; Full time

Job summary

Join a dynamic start-up at the forefront of oncology therapeutics as a Principal Scientist. This role offers an exciting opportunity to lead the development of innovative drug candidates, including Antibody Drug Conjugates and Bispecific Antibodies. You will balance laboratory work with project leadership, fostering collaborations with external partners to drive portfolio expansion. If you have a PhD and a passion for translating scientific discoveries into impactful therapies, this is your chance to make a significant contribution in a fast-paced environment. Be part of a team that is revolutionizing cancer treatment and improving patient outcomes.

Qualifications

• PhD with experience in oncology biologics, ideally ADCs or Bispecific Antibodies.
• Strong expertise in primary cell culture and flow cytometry.

Responsibilities

• Develop novel oncology therapeutics and manage project leadership.
• Deliver pivotal in vivo proof of concept data via external partners.

Skills

Oncology Therapeutics Development

Antibody Drug Conjugates (ADCs)

Bispecific Antibodies

Primary Cell Tissue Culture

Flow Cytometry

IHC Assay Development

Education

PhD in Relevant Field

Tools

Laboratory Equipment

Job description

Job Description

A fantastic opportunity has arisen for a Principal Scientist – Discovery & Translational Biology to join a high-potential drug-development start-up, focused on developing new oncology therapeutics that significantly improve overall survival for patients with a high unmet need. Our client is at the cutting edge of oncology therapeutics, using proprietary algorithms to identify novel protein fingerprints from a comprehensive membrane protein database, thereby triggering a new wave in target discovery.

They are establishing their own laboratory to support their ambitious growth plans and are seeking a highly motivated Principal Scientist to join their Research Group. This role offers an exciting opportunity for the right candidate to contribute significantly across discovery and translational sciences.

KEY DUTIES AND RESPONSIBILITIES:

Your duties as the Principal Scientist will be varied; however, the key responsibilities include:

• Developing novel oncology therapeutics, ideally Antibody Drug Conjugates (ADCs) or Bispecific Antibodies.
• Balancing laboratory work with project leadership and building successful relationships with external partners.
• Supporting portfolio expansion through target validation and co-expression studies.
• Developing workflows for hit selection and lead triage.
• Delivering pivotal in vivo proof of concept data via external partners.

ROLE REQUIREMENTS:

To be successful in this role, candidates should demonstrate:

1. A PhD in a relevant field with significant experience in developing novel oncology biologics, ideally ADCs or Bispecific Antibodies, gained within a commercial biotech or biopharma environment.
2. Strong expertise in primary cell tissue culture, flow cytometry, and IHC assay development and execution. Experience with spheroids is desirable.
3. Ability to work independently and proactively in a start-up environment.