Senior Scientific Researcher in Single-Molecule Biophysics

TN United Kingdom; Oxford; On-site; GBP 40,000 - 60,000; Full time

Job summary

A leading research institution in Oxford is seeking a Senior Scientific Researcher specializing in Single-Molecule Biophysics. The role involves leading innovative research on DNA replication and chromatin organization, requiring a Ph.D. and experience in biophysical instrumentation. The successful candidate will contribute to groundbreaking research and mentor students, with an aim to start by summer or fall 2025.

Benefits

UK visa costs covered

NHS surcharge fees covered

Qualifications

• Ph.D. in biophysics or optical physics required.
• Experience in biophysical instrumentation and microscopy.
• Strong skills in hardware-software interfacing.

Responsibilities

• Lead research in single-molecule biophysics.
• Design and implement biophysical instrumentation.
• Guide and train graduate students and postdocs.

Skills

Biophysical instrumentation

Microscopy

Force spectroscopy

Interpersonal communication

Education

Ph.D. degree in biophysics or optical physics

Tools

Optical tweezers

Magnetic tweezers

Atomic force microscopy

Job description

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Senior Scientific Researcher in Single-Molecule Biophysics, Oxford

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Client:

University of Oxford

Location:

Oxford, United Kingdom

Job Category:

Other

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EU work permit required:

Yes

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Job Reference:

d064d59dd776

Job Views:

2

Posted:

23.05.2025

Expiry Date:

07.07.2025

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Job Description:

Department of Physics, Clarendon Laboratory and Kavli Institute We are looking to hire an outstanding senior scientific staff member to support our group’s research, which focuses on studying DNA and chromatin replication at the single-molecule level. You will form part of the research team core and support the wider group by leading outstanding research and development in single-molecule biophysics. About the projectIn this project, you will design and implement novel forms of biophysical instrumentation (e.g. advanced optical tweezers and magnetic tweezers, single-molecule fluorescence, novel single-molecule approaches to DNA sequencing, integration with cryo-EM) with the goal of maximizing their contributions to the understanding of DNA replication and/or chromatin organization. You will propose and/or implement technical advances on single-molecule instruments and use them together with graduate students and postdocs to acquire data on DNA replication and/or chromatin organization. An aptitude in instrumentation development and quantitative biophysics, a willingness to acquire relevant knowledge into the photophysics of fluorescent labels, and an interest in guiding, coaching, and training graduate students and postdocs in their scientific and technical development, are essential. The overall goal is to provide novel and sound single-molecule biophysical insights into DNA replication and/or chromatin organization to advance these exciting fields. RequirementsFor this innovative, interdisciplinary project, we are looking a (bio)physicist, with:• A successfully completed Ph.D. degree in biophysics or optical physics.• Practical experience and scientific maturity in the above areas.• Strong aptitude and interest in biophysical instrumentation and microscopy, and willingness to acquire related knowledge e.g. photophysics.• Professional experience with force spectroscopy (e.g. optical tweezers, magnetic tweezers, or atomic force microscopy) or single-molecule fluorescence methodologies.• Strong skills in hardware-software interfacing and demonstrable ability to interface and collaborate with experts in programming.• An independent, well-organized, and reliable work style.• Track record of obtaining scientific funding.• Leadership ability to guide, coach, and train graduate students and postdocs in the context of an interdisciplinary team.• Excellent interpersonal communication skills and a strong interest in the broader field of biophysics that will contribute to the interactive lab culture. We look for friendly and driven colleagues to enrich our team. UK visa costs and NHS surcharge fees will be covered. We would like to welcome our new colleague by the summer or fall of 2025. Who are we? Information and applicationIf you're excited about contributing to innovative biophysical research and collaborating with a talented team, we’d love to hear from you! Applications should include a motivated cover letter of application, a detailed CV, and the names and contact information of three references, with the final deadline for applications being 12 noon on 31 May, 2025.