Postdoctoral Research Assistant in single-molecule biophysics of DNA damage-induced transcripti[...]

TN United Kingdom; Oxford; On-site; GBP 35,000 - 55,000; Full time

Job summary

An established industry player is seeking a talented Postdoctoral Research Assistant for an innovative project at the intersection of biophysics and biochemistry. This role involves utilizing advanced biophysical instrumentation to explore RNA polymerase's response to DNA damage-induced transcription stress. With opportunities for collaboration across disciplines and the chance to gain teaching experience, this position promises to enhance your scientific skills and contribute to groundbreaking research. Join a dynamic team at a prestigious institution and make a meaningful impact in the field of molecular biology.

Qualifications

• Ph.D. degree or close to completion in quantitative biochemistry or biophysics.
• Strong experimental and quantitative skills with practical experience.

Responsibilities

• Employ advanced biophysical instrumentation to study RNA polymerase.
• Develop interdisciplinary skills and collaborate with biochemists.

Skills

Quantitative Biochemistry

Biophysics

Experimental Skills

Data Analysis

Interpersonal Communication

Education

Ph.D. in Quantitative Biochemistry or Biophysics

Tools

Optical Trapping

Fluorescence Microscopy

Protein Purification Techniques

Job description

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Postdoctoral Research Assistant in single-molecule biophysics of DNA damage-induced transcription stress, Oxford

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Client:

University of Oxford

Location:

Oxford, United Kingdom

Job Category:

Other

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EU work permit required:

Yes

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Job Reference:

383de6f97493

Job Views:

4

Posted:

05.05.2025

Expiry Date:

19.06.2025

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Job Description:

Condensed Matter Physics, Department of Physics, Clarendon Laboratory Building and Kavli Institute, Oxford, OX1. We are looking to hire an outstanding experimentalist for an exciting project at the interface of biophysics and biochemistry that aims to understand the response of RNA polymerase to DNA damage-induced transcription stress. This is a fixed-term position for 3 years.

What are you going to do?

• Employ advanced biophysical instrumentation based on optical trapping or fluorescence microscopy to study RNA polymerase and its response to DNA damage-induced transcription stress;
• Develop an interdisciplinary skillset by acquiring practical knowledge of protein purification, ensemble biochemistry, and sample preparation to support your biophysical studies;
• Interact with biochemist and structural biology collaborators at Oxford and in the Netherlands (Erasmus MC and Netherlands Cancer Institute) in collaborative projects;
• Suggest ways to expand the interdisciplinary skillset as needed for the project's benefit;
• Employ simulations and data analysis routines to analyze your data;
• Publish your results with collaborators;
• Have the opportunity to gain teaching experience and improve leadership skills while guiding undergraduate and graduate students.

About the project

Requirements

For this innovative, interdisciplinary project, we seek an excellent scientist with:

• A successfully completed Ph.D. degree (or close to completion) in quantitative biochemistry or biophysics;
• Practical experience and scientific maturity in these areas;
• Strong experimental and quantitative skills;
• An interest in working at the interface of biophysics, biochemistry, and structural biology (and developing relevant skills if not already present);
• An independent, well-organized, and reliable work style, with the ability and interest to work in a small team;
• Good interpersonal communication skills and a strong interest in the broader fields of replication and transcription, contributing to collaborative work and our interactive lab culture.

We welcome friendly and driven colleagues to enrich our team. We aim to onboard our new colleague in fall 2025.

Who are we?

Information and application