Senior Principal Toxicology Scientist

TN United Kingdom; London; Hybrid; GBP 80,000 - 100,000; Full time

Job summary

A leading company in drug discovery is seeking a Senior Principal Toxicology Scientist in London. The role involves leading safety studies, guiding project strategies, and collaborating with a small team. Candidates should have extensive experience in toxicology and a strong educational background. Hybrid working options are available.

Qualifications

• 10+ years’ experience in toxicology across disease areas.
• Experience as a safety lead in multifunctional project teams.

Responsibilities

• Lead toxicologist defining safety and toxicology strategies.
• Analyze and present toxicology data to project teams.
• Develop and review study protocols with CROs.

Skills

Interpersonal Skills

Communication

Collaboration

Organizational Skills

Education

BSc/MSc/PhD in Toxicology

BSc/MSc/PhD in Pharmacology

BSc/MSc/PhD in Biochemistry

Tools

Lhasa Ltd NEXUS platform

Job description

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Senior Principal Toxicology Scientist, London

Client:

Location:

London, United Kingdom

Job Category:

Other

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EU work permit required:

Yes

Job Reference:

62a403441c54

Job Views:

3

Posted:

12.05.2025

Expiry Date:

26.06.2025

Job Description:

Reporting to the VP DMPK and Safety, you will be an experienced, highly motivated toxicologist, joining a small team responsible for leading safety studies and strategy in support of Benevolent’s drug discovery and development portfolio. You will provide clear guidance based on experience to Principal and Senior Scientists and influence project strategies through strong interpersonal skills.

With hybrid working from home and our London or Cambridge offices, you will be a core member of drug discovery project teams, acting as the safety point of contact to advance programs from early discovery to the clinic.

Responsibilities

• Lead toxicologist within the DMPK and Safety department to define safety and toxicology strategies from TID to clinical phases.
• Lead, perform, and review target safety assessments, developing mitigation strategies using various data sources and tools.
• Ensure appropriate toxicology screening strategies are applied to predict and mitigate safety risks.
• Develop and review study protocols and reports with CROs, ensuring quality and timelines.
• Analyze, interpret, and present toxicology data to project teams, updating risk assessments and guiding project decisions.
• Provide guidance to Principal and Senior Scientists based on prior experience.
• Review in vitro toxicology studies and oversee CROs providing nonclinical study services.

We are looking for:

• BSc/MSc/PhD in toxicology, pharmacology, biochemistry, or a related discipline.
• 10+ years’ experience in toxicology, with broad knowledge across disease areas.
• Experience in leading, managing, and developing staff.
• Hands-on experience assessing the safety of targets and devising screening strategies.
• Understanding of in vitro to in vivo translation of toxicities and human safety implications.
• Strong interpersonal, communication, collaboration, and organizational skills.
• Experience as a safety lead in multifunctional project teams.
• Track record in drug discovery and development, including late-stage regulatory safety packages.
• Experience in in silico and in vitro safety assessment, with knowledge of discovery toxicology and exploratory studies, including experience with Lhasa Ltd NEXUS platform.