Senior Scientist - DMPK

CANCER RESEARCH UK; Cambridge; On-site; GBP 41,000 - 47,000; Full time

Job summary

Join a dynamic team at a leading medical research charity as a Senior Scientist in DMPK. This role offers the chance to contribute to groundbreaking cancer research by conducting vital bioanalysis and pharmacokinetic studies. Collaborate with cross-functional teams and leverage cutting-edge technology to accelerate the development of new cancer treatments. With a commitment to innovation and inclusivity, this position not only promises professional growth but also the opportunity to make a significant impact in the fight against cancer. If you are passionate about science and dedicated to improving patient outcomes, this is the perfect opportunity for you.

Benefits

Pension contribution up to 12%

Income protection

Flexible working hours

Career development opportunities

Qualifications

• Experience in bioanalysis and in vitro ADME assays.
• PhD or BSc/MSc with relevant experience in life sciences.

Responsibilities

• Conduct and report in vitro ADME assays and bioanalysis.
• Plan and interpret pharmacokinetic studies.

Skills

Bioanalysis

In vitro ADME assays

Pharmacokinetic analysis

Time management

Communication skills

Education

PhD in Life Sciences

BSc/MSc in Life Sciences

Tools

LC-MS/MS

Phoenix WNL

Job description

200 staff. Limitless Potential. One team - Cancer Research Horizons.

Senior Scientist - DMPK (Under the leadership of Kevin Doyle )

Salary: £41,700 - £46,500 per annum (dependent on experience) plus benefits (includes up to 12% pension contribution and income protection)

Reports to: Group Lead DMK

Department: Research and Innovation

Contract: Fixed Term Contract

Hours: Full time 35 hours per week (flexible working requests considered if they meet business needs)

Location: Babraham Research Campus, Cambridge

Closing date: 26 May 2025 23:55 This vacancy may close earlier if a high volume of applications is received or once a suitable candidate is found, therefore we strongly recommend that you apply early to avoid disappointment. If you require more time to apply as part of a reasonable adjustment, please contact as soon as possible.

Visa Sponsorship: Cancer Research UK is NOT able to consider visa sponsorship for this vacancy.

Recruitment Process: 1st Stage Screening call via Microsoft Teams, 2nd stage in person interview at Babraham consisting of competency-based interview questions and a case study, which you will be sent in advance.

Interview date: W/C 2 June 2025 screening, W/C 9 June 2025 in person interview

At Cancer Research UK, we exist to beat cancer.

We are currently recruiting for a Drug Metabolism and Pharmacokinetics (DMPK) Senior Scientist on a fixed term contract as a maternity cover to join our team based on the Babraham Research Campus, Cambridge.

About Cancer Research Horizons

As the world's biggest medical research charity, we've helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster.

We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UK's established drug discovery teams under one organisation and leadership team, combining our unique pipeline of cancer biology expertise and access to CRUK's world-class academic network, cutting edge technology platforms and clinical expertise to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success.

Based at sites in Cambridge, the CRUK Scotland Institute in Glasgow, the Francis Crick Institute in London, and Newcastle University, Cancer Research Horizons employs ~200 staff from both industrial and academic backgrounds

This lab-based position involves conducting bioanalysis, in vitro ADME assays, pharmacokinetic and pharmacokinetic/pharmacodynamic analysis relevant to understanding the metabolism and disposition of potential drug candidates. Reporting directly to the DMPK Group lead, you will work closely with the medicinal chemistry team and more widely with cross functional teams, seeking to accelerate novel therapies into clinical development.

The role would suit a senior scientist with a PhD or BSc/MSc with relevant experience in a life sciences discipline and industrial pharmaceutical laboratory experience. Good time management skills, a proven ability to form close and effective relationships with colleagues at all levels and excellent written and verbal communication skills are essential

We work in an inclusive environment where we welcome creative thinking and new ideas, we would welcome your input on implementation of new technologies and improvements to existing processes and infrastructure. Furthermore, we actively encourage our colleagues to celebrate our science, by attending conferences, presenting posters, giving talks at events and publishing papers. You will form an integral part of the Cancer Research Horizon Drug Discovery team working alongside our industry and academic partners to progress novel cancer targets towards patient benefit.

What will I be doing?

• Conduct, interpret and report in vitro ADME assays
• Plan outsourced in vivo PK and PK/PD studies
• Perform, interpret and report bioanalysis internally by LC-MS/MS
• Perform and interpret pharmacokinetic analysis using Phoenix WNL or any other software
• Act as a DMPK lead on drug discovery projects where appropriate
• Communicate efficiently, interpret, summarise and present data across departments, project teams and to alliance partners
• Work collaboratively within the drug discovery project teams and interact with multi-disciplinary research teams both internally and with external stakeholders
• Prioritise own workload according to project goals and take responsibility for the timely delivery of key data
• Perform work within COSHH safety regulations and Cancer Research Horizons safety policies

What are you looking for?

• A PhD or BSc/MSc with relevant experience in a life sciences discipline, coupled with industrial pharmaceutical laboratory experience.
• Practical experience of bioanalysis.
• Practical knowledge of in vitro ADME assays to determine microsomal stability, hepatocyte stability, protein binding and permeability
• Experience of working in an industrial drug discovery setting.
• Excellent time management skills.
• Proven ability to form effective relationships with cross disciplinary teams.
• Good written and verbal communication skills
• Experience of driving scientific or strategic areas aligned to organisational objectives
• Evidence of growing external reputation through presentations and publications

Our organisation values are designed to guide all that we do.

Bold: Act with ambition, courage and determination

Credible: Act with rigour and professionalism

Human: Act to have a positive impact on people

Together: Act inclusively and collaboratively

We're looking for people who can believe in and embody these organisation values and can use them to drive forward progress against our mission to beat cancer.

If you're interested in applying and excited about working with us but are unsure if you have the right skills and experience we'd still love to hear from you.

What will I gain?

We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career and achieve your personal wellbeing goals.

You can explore our benefits by visiting our careers web page.

How do I apply?

We operate an anonymised shortlisting process in our commitment to equality, diversity and inclusion. CVs are required for all applications; but we won't be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively.

For more information on this career opportunity please visit our website or contact us.

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