Cryo-EM Explorer: Lipid-Enveloped Virus Entry & Assembly

Crick; Greater London; Hybrid; GBP 18,000 - 21,000; Full time

Job summary

The Crick invites applications for a 2027 PhD project led by Peter Rosenthal. The successful candidate will join a group studying virus entry and membrane fusion using cryo-EM and cryo-ET to image influenza and retroviruses, with a focus on glycoprotein-mediated fusion and assembly.

Training spans single particle cryo-EM, cryo-ET, FIB-milling, subtomogram averaging, and computational image analysis, complemented by protein, membrane and virus methods and light microscopy.

Qualifications

• Background in structural biology, virology or cell biology.
• Experience with experimental methods in molecular biology or virology.
• Interest in electron imaging or computation is encouraged.

Responsibilities

• Receive training in cryo-EM, cryo-ET and subtomogram averaging.
• Conduct experimental cryomicroscopy and imaging of viruses and proteins.
• Engage in computational image analysis and data interpretation.
• Contribute to publications and present findings within the lab.

Skills

Structural biology

Virology

Cryo-EM

Computational analysis

Education

Bachelor's degree in biology

Tools

Cryo-EM

Cryo-ET

FIB-milling

Subtomogram averaging

Job description

The Crick invites applications for a 2027 PhD project led by Peter Rosenthal. The successful candidate will join a group studying virus entry and membrane fusion using cryo-EM and cryo-ET to image influenza and retroviruses, with a focus on glycoprotein-mediated fusion and assembly.

Training spans single particle cryo-EM, cryo-ET, FIB-milling, subtomogram averaging, and computational image analysis, complemented by protein, membrane and virus methods and light microscopy.