Bioinformatician/Computational Biologist

Institute for Modern; Greater London; Hybrid; GBP 44,000 - 54,000; Full time

Job summary

The Francis Crick Institute in London is seeking a talented Bioinformatician to join a multidisciplinary team on a five-year ERC Synergy-funded project. You will analyse and integrate complex genomic, transcriptomic and epigenetic data, including bulk and single-cell RNA-seq, ATAC-seq, ChIP-seq, methylome and proteomics.

You will help shape experimental design, identify patterns and translate computational findings into new biological hypotheses for testing, collaborating with the Malanchi Lab

Qualifications

• Degree in Bioinformatics, Computer Science or a related discipline.
• Strong programming skills using Python, R, Java, C/C++ or Perl.
• Hands-on experience with NGS, single-cell RNA-seq and ATAC-seq.
• Experience with databases and data management.
• Experience analysing and integrating complex biological datasets.

Responsibilities

• Analysing and integrating large-scale genomic and multi-omic datasets.
• Working with bulk and single-cell RNA-seq, ATAC-seq, ChIP-seq, methylome and proteomic data.
• Developing computational approaches and algorithms to answer complex biological questions.
• Identifying patterns and signatures within datasets and translating these into meaningful biological insights.
• Working with scientists to inform experimental design and data interpretation.
• Developing and maintaining bioinformatics tools, software and databases.
• Ensuring data quality and integrity throughout the analysis process.
• Communicating findings through project discussions, presentations, reports and publications.
• Keeping up to date with emerging approaches and technologies across bioinformatics.

Skills

Genomics data analysis

Next-gen sequencing

Single-cell RNA-seq

UNIX/Linux

Programming (Python, R, Java, C/C++,/P

Databases

Data integration

Education

Degree in Bioinformatics / Computer Science

Tools

UNIX/Linux tools

Job description

Location: The Francis Crick Institute, London

Short summary

We are looking for a talented and motivated Bioinformatician to join our multidisciplinary team as part of a five-year ERC Synergy-funded research programme.

You’ll work with scientists across the project to analyse and integrate complex genomic, transcriptomic and epigenetic datasets, including bulk and single-cell RNA‑seq, ATAC‑seq, ChIP‑seq, methylome and proteomic data.

This is more than a data analysis role. You’ll have the opportunity to influence experimental design, identify interesting patterns and signatures within large datasets and help translate computational findings into new biological hypotheses that can be tested experimentally.

You’ll join the Malanchi Lab at the Crick and collaborate closely with the groups of Professor Dominique Bonnet and Professor Francesca Ciccarelli as part of the wider ERC Synergy programme.

Key Responsibilities

• Analysing and integrating large-scale genomic and multi‑omic datasets
• Working with bulk and single‑cell RNA‑seq, ATAC‑seq, ChIP‑seq, methylome and proteomic data.
• Developing computational approaches and algorithms to answer complex biological questions.
• Identifying patterns and signatures within datasets and translating these into meaningful biological insights.
• Working with scientists to inform experimental design and data interpretation.
• Developing and maintaining bioinformatics tools, software and databases.
• Ensuring data quality and integrity throughout the analysis process.
• Communicating findings through project discussions, presentations, reports and publications.
• Keeping up to date with emerging approaches and technologies across bioinformatics.

About you

You will have:

• A degree in Bioinformatics, Computer Science or a related discipline, alongside a scientific background.*
• Strong programming skills using languages such as Python, R, Java, C/C++ or Perl.*
• Hands‑on experience analysing next‑generation sequencing, single‑cell RNA‑seq and ATAC‑seq data.*
• Experience working with and developing software within UNIX/Linux environments.*
• Experience with databases and data management.*
• Experience analysing and integrating complex biological datasets.*

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state‑of‑the‑art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under one building in Europe.

The Francis Crick Institute will be world‑class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it to the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

From £49,080 with benefits, subject to skills & experience