Bioinformatician/Computational Biologist

The Francis Crick Institute Limited; Greater London; Hybrid; GBP 45,000 - 55,000; Full time

Benefits offered by this job

Generous Leave

Pension Scheme

GP Services

On-site restaurant

Wellbeing support

Job summary

The Francis Crick Institute is seeking a Bioinformatician/Computational Biologist to join the Malanchi Lab on a five-year ERC Synergy-funded programme in London. The role focuses on analysing and integrating genomic, transcriptomic and epigenetic data, including single-cell RNA-seq, ATAC-seq and ChIP-seq, to generate biological insights.

You will collaborate with scientists to inform experimental design, develop computational approaches, and translate findings into testable hypotheses while

Qualifications

• Degree in Bioinformatics, Computer Science or a related discipline.
• Strong programming skills using Python, R, Java, C/C++ or Perl.
• Experience applying statistical methods to biological data.
• Hands-on experience analysing next-generation sequencing, single-cell RNA-seq and ATAC-seq data.
• Experience working with and developing software within UNIX/Linux environments.
• Experience with databases and data management.
• A strong understanding of bioinformatics approaches within genomics and transcriptomics.
• Experience analysing and integrating complex biological datasets.
• Ability to interpret scientific literature and apply insights to research projects.
• Strong communication skills and ability to explain findings to technical and non-technical audiences.
• Collaborative approach and enthusiasm for working with experimental scientists.

Responsibilities

• Analysing and integrating large-scale genomic and multi-omic datasets.
• Working with bulk and single-cell RNA-seq, ATAC-seq, ChIP-seq, methylome and proteomic data.
• Developing computational approaches and algorithms to answer complex biological questions.
• Identifying patterns and signatures within datasets and translating these into meaningful biological insights.
• Working with scientists to inform experimental design and data interpretation.
• Developing and maintaining bioinformatics tools, software and databases.
• Ensuring data quality and integrity throughout the analysis process.
• Communicating findings through project discussions, presentations, reports and publications.
• Keeping up to date with emerging approaches and technologies across bioinformatics.

Skills

Python

R

Java

C/C++

Perl

Education

Degree in Bioinformatics or related discipline

Tools

UNIX/Linux

Job description

Bioinformatician/Computational Biologist

Contract term: This is a full-time, fixed term (5 years) position on Crick terms and conditions of employment.

Reporting to: Ilaria Malanchi, Principal Group Leader

Salary for this Role: From £49,790 with benefits, subject to skills and experience

About us

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the Malanchi Lab

The Tumour Host Interaction Lab, led by Professor Ilaria Malanchi, investigates how cancer cells interact with surrounding tissues and distant organs to create environments that support tumour growth, metastasis and treatment resistance.

Our research explores the relationship between cancer, ageing, inflammation and tissue regeneration, combining sophisticated experimental models with genomic and multi-omic approaches to uncover the mechanisms driving disease.

About the role

We are looking for a talented and motivated Bioinformatician to join our multidisciplinary team as part of a five-year ERC Synergy-funded research programme.

You’ll work with scientists across the project to analyse and integrate complex genomic, transcriptomic and epigenetic datasets, including bulk and single-cell RNA-seq, ATAC-seq, ChIP-seq, methylome and proteomic data.

This is more than a data analysis role. You’ll have the opportunity to influence experimental design, identify interesting patterns and signatures within large datasets and help translate computational findings into new biological hypotheses that can be tested experimentally.

You’ll join the Malanchi Lab at the Crick and collaborate closely with the groups of Professor Dominique Bonnet and Professor Francesca Ciccarelli as part of the wider ERC Synergy programme.

• Analysing and integrating large-scale genomic and multi-omic datasets
• Working with bulk and single-cell RNA-seq, ATAC-seq, ChIP-seq, methylome and proteomic data.
• Developing computational approaches and algorithms to answer complex biological questions.
• Identifying patterns and signatures within datasets and translating these into meaningful biological insights.
• Working with scientists to inform experimental design and data interpretation.
• Developing and maintaining bioinformatics tools, software and databases.
• Ensuring data quality and integrity throughout the analysis process.
• Communicating findings through project discussions, presentations, reports and publications.
• Keeping up to date with emerging approaches and technologies across bioinformatics.

About you

You will have:

• A degree in Bioinformatics, Computer Science or a related discipline, alongside a scientific background.*
• Strong programming skills using languages such as Python, R, Java, C/C++ or Perl.*
• Experience applying statistical methods to biological data.
• Hands-on experience analysing next-generation sequencing, single-cell RNA-seq and ATAC-seq data.*
• Experience working with and developing software within UNIX/Linux environments.*
• Experience with databases and data management.*
• A strong understanding of bioinformatics approaches within genomics and transcriptomics.
• Experience analysing and integrating complex biological datasets.*
• The ability to interpret scientific literature and apply this to research projects.
• Strong communication skills and the ability to explain findings to both technical and non-technical audiences.
• A collaborative approach and enthusiasm for working closely with experimental scientists.

Experience or knowledge of molecular biology, genetics and related biological fields would be advantageous.

This is an exciting opportunity to play a key computational role in an ambitious, collaborative research programme, using cutting-edge multi-omic approaches to uncover how interactions between tumours and their host environment shape cancer development and progression.

About Working at the Crick

Our values

Everyone who works at the Crick has a valuable role to play in advancing the Crick’s mission and shaping our culture!

• We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently.
• We are open. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world.
• We are collegial. We show respect for one another, work cooperatively and support the wider community.

At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences.Weare aDisability Confident: Committedemployer andwant to ensure that everyone can apply and be part of our recruitment processes and sowe'llmake reasonable adjustments if you need them - just let us know when you apply. If you needassistancewith applying (i.e., would like to apply by phone or post)please email: [e-mail].

At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development:

• Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.
• Pension Scheme: Defined contribution pension with employer contributions of up to 16%.
• 24/7 GP consultation services.
• Occupational health services and mental health support programs.
• Eye care vouchers and discounted healthcare plans.
• Work-Life Balance:
• Childcare support allowance.
• Annual leave purchase options.
• Crick Networks offering diverse groups’ support, community and inclusive social events.
• Discounted gym memberships, bike-to-work scheme, and shopping discounts.
• Subsidised on-site restaurant and social spaces for team interaction.

Please note you must meet the essential criteria listed within the Role Profile, to have your application reviewed. We reserve the right to withdraw this advert at any given time due to the number of applications received.