Bioinformatician/Computational Biologist

Francis Crick Institute Ltd; Greater London; On-site; GBP 49,000 - 50,000; Full time

Benefits offered by this job

On-site restaurant

Discounted gym memberships

Health and well-being programs

Job summary

The Francis Crick Institute is seeking a Bioinformatician/Computational Biologist for a full-time, fixed-term (5 years) position in London. You will analyse complex genomic and multi-omic datasets, including bulk and single-cell RNA-seq, ATAC-seq and ChIP-seq, and contribute to experimental design and data interpretation within the Malanchi Lab.

You will develop and maintain bioinformatics tools, work in UNIX/Linux environments, and collaborate with scientists to translate computational findings

Qualifications

• A degree in Bioinformatics, Computer Science or a related discipline.
• Strong programming skills in Python, R, Java, C/C++ or Perl.
• Hands-on experience with NGS data (bulk and single-cell RNA-seq, ATAC-seq).
• Experience with UNIX/Linux environments and data management.

Responsibilities

• Analyze and integrate large-scale genomic and multi-omic datasets.
• Work with bulk and single-cell RNA-seq, ATAC-seq, ChIP-seq, methylome and proteomic data.
• Develop computational approaches and algorithms to answer complex biological questions.
• Identify patterns and signatures within datasets and translate into biological insights.
• Collaborate with scientists to inform experimental design and data interpretation.
• Develop and maintain bioinformatics tools, software and databases.
• Ensure data quality and integrity throughout the analysis process.
• Communicate findings through project discussions, reports and publications.
• Keep up to date with emerging bioinformatics approaches.

Skills

Python

R

Java/C/C++/Perl

UNIX/Linux

DB/Data management

Education

Bioinformatics or Computer Science degree

Related discipline

Tools

UNIX/Linux

Databases

Job description

Salary for this Role: From £49,080 , plus benefits, subject to skills and experience Job Title: Bioinformatician/Computational Biologist Reports to: Ilaria Malanchi Closing Date: 18/Oct/2026 23.59 GMT Job Description: Bioinformatician/Computational Biologist Contract term: This is a full-time, fixed term (5 years) position on Crick terms and conditions of employment. Reporting to: Ilaria Malanchi, Principal Group Leader Salary for this Role: From £49,790 with benefits, subject to skills and experience

About us

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world‑class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state‑of‑the‑art infrastructure, cutting‑edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high‑quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the Malanchi Lab

The Tumour Host Interaction Lab, led by Professor Ilaria Malanchi, investigates how cancer cells interact with surrounding tissues and distant organs to create environments that support tumour growth, metastasis and treatment resistance. Our research explores the relationship between cancer, ageing, inflammation and tissue regeneration, combining sophisticated experimental models with genomic and multi‑omic approaches to uncover the mechanisms driving disease.

About the role

We are looking for a talented and motivated Bioinformatician to join our multidisciplinary team as part of a five‑year ERC Synergy‑funded research programme. You’ll work with scientists across the project to analyse and integrate complex genomic, transcriptomic and epigenetic datasets, including bulk and single‑cell RNA‑seq, ATAC‑seq, ChIP‑seq, methylome and proteomic data. This is more than a data analysis role. You’ll have the opportunity to influence experimental design, identify interesting patterns and signatures within large datasets and help translate computational findings into new biological hypotheses that can be tested experimentally. You’ll join the Malanchi Lab at the Crick and collaborate closely with the groups of Professor Dominique Bonnet and Professor Francesca Ciccarelli as part of the wider ERC Synergy programme.

What you’ll be doing

• Analysing and integrating large‑scale genomic and multi‑omic datasets
• Working with bulk and single‑cell RNA‑seq, ATAC‑seq, ChIP‑seq, methylome and proteomic data
• Developing computational approaches and algorithms to answer complex biological questions
• Identifying patterns and signatures within datasets and translating these into meaningful biological insights
• Working with scientists to inform experimental design and data interpretation
• Developing and maintaining bioinformatics tools, software and databases
• Ensuring data quality and integrity throughout the analysis process
• Communicating findings through project discussions, presentations, reports and publications
• Keeping up to date with emerging approaches and technologies across bioinformatics

About you

• A degree in Bioinformatics, Computer Science or a related discipline, alongside a scientific background.
• Strong programming skills using languages such as Python, R, Java, C/C++ or Perl.
• Experience applying statistical methods to biological data.
• Hands‑on experience analysing next‑generation sequencing, single‑cell RNA‑seq and ATAC‑seq data.
• Experience working with and developing software within UNIX/Linux environments.
• Experience with databases and data management.
• A strong understanding of bioinformatics approaches within genomics and transcriptomics.
• Experience analysing and integrating complex biological datasets.
• The ability to interpret scientific literature and apply this to research projects.
• Strong communication skills and the ability to explain findings to both technical and non‑technical audiences.
• A collaborative approach and enthusiasm for working closely with experimental scientists.
• Experience or knowledge of molecular biology, genetics and related biological fields would be advantageous.

About Working at the Crick

Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick’s mission and shaping our culture! We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently. We are open. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and want to ensure that everyone can apply and be part of our recruitment processes and so we’ll make reasonable adjustments if you need them.

What will you receive?

• Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.
• Pension Scheme: Defined contribution pension with employer contributions of up to 16%.
• Health & Well‑being: 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans.
• Work‑Life Balance: Back‑up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups’ support, community and inclusive social events.
• Perks: Discounted gym memberships, bike‑to‑work scheme, and shopping discounts. Subsidised on‑site restaurant and social spaces for team interaction.

Please note you must meet the essential criteria listed within the Role Profile, to have your application reviewed. We reserve the right to withdraw this advert at any given time due to the number of applications received.

The Francis Crick Institute is a biomedical discovery institute researching the biology underlying human health. At the Crick, scientists and staff collaborate to stretch the very limits of what we know about how life works. Our work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections and neurodegenerative diseases. The Francis Crick Institute is a charity, founded by the Medical Research Council, Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.