Analytical Principal Scientist: Method Dev & Leadership

Nexus Life Sciences; Stone Cross; On-site; GBP 110,000 - 150,000; Full time

Job summary

Nexus Life Sciences is seeking a Principal Scientist (Analytical) to provide senior scientific leadership and hands-on expertise across a diverse client portfolio. Lead analytical strategy, method development, and data integrity in regulated environments.

You will mentor colleagues, drive capability building, and collaborate with multidisciplinary teams to ensure high-quality data delivery and compliant outcomes.

Qualifications

• PhD in Chemistry or equivalent postgraduate qualification.
• Proven experience leading analytical development programs in regulated environments.
• Strong data integrity and regulatory compliance awareness.
• Experience in GMP-regulated analytical laboratories.

Responsibilities

• Lead analytical strategy and delivery across small molecules and emerging modalities.
• Design, execute, and interpret complex analytical studies to support process development and investigations.
• Provide expertise across techniques such as UPLC‑MS, SFC, NMR, GC‑MS and advanced characterisation methods.
• Drive method development, validation, troubleshooting, and continuous improvement.
• Collaborate with R&D chemists, process chemists, project teams, QA colleagues, and clients.
• Uphold the highest standards of data integrity, safety, and regulatory compliance.
• Mentor and develop scientists, supporting capability building and knowledge sharing.
• Manage projects effectively, ensuring timelines, quality, and client expectations are met.

Skills

PhD in Chemistry

Method development / analytical

Drug substance / API analytics

Project management

GMP-regulated labs

Data integrity & compliance

Analytical instrumentation (LC-MS, GC‑

Education

PhD in Chemistry

Job description

Nexus Life Sciences is seeking a Principal Scientist (Analytical) to provide senior scientific leadership and hands-on expertise across a diverse client portfolio. Lead analytical strategy, method development, and data integrity in regulated environments.

You will mentor colleagues, drive capability building, and collaborate with multidisciplinary teams to ensure high-quality data delivery and compliant outcomes.