Analytical Development Scientist – Nucleic Acids & LNP

flagshippioneeringinc; Cambridge; On-site; GBP 45,000 - 65,000; Full time

Job summary

Serif Biomedicines is seeking a Scientist I to join the Analytical Development and Quality Control team in a fast-paced, entrepreneurial setting. The role focuses on building efficient systems for testing samples and delivering data, with method development for nucleic acid cargo and LNP delivery vehicles.

You will mentor colleagues, contribute to platform goals, and communicate results clearly in both oral and written formats, while maintaining rigorous records and SOPs within Benchling.

Qualifications

• Degree in Chemistry, Biochemical Engineering, Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology or related field. B.S. degree with 10+ years, M.S. degree with 8+ years, Ph.D. with 0+ years of relevant industry experience
• Technical expertise in HPLC separations and plate-based assays (e.g. ELISA, qPCR/dPCR, residual protein)
• Prior hands-on experience with HPLC methods for nucleic acid cargo and nanoparticle delivery vehicles (e.g. LNPs or liposomes) is highly desired
• Proven ability to independently design, execute, and troubleshoot complex experiments
• Experience mentoring, training, or providing technical guidance to junior staff is desired
• Strong communication and organization skills; familiarity with Benchling, MS Office, JMP, GraphPad, Empower, Chromeleon
• Demonstrates meticulous record keeping and attention to detail
• Ability to analyze and present experimental data in oral and written formats

Responsibilities

• Drive advancement of platform development and shape analytical capabilities.
• Setup, maintain, and optimize a system for sample testing and data delivery.
• Ensure robustness of generated data by tracking historical data.
• Conduct method development to support nucleic acid cargo and LNP product release, stability, and characterization.
• Lead experimental studies to optimize analytical method performance (specificity, sensitivity, precision, accuracy).
• Analyze, troubleshoot, and communicate experimental findings clearly in oral, written, and visual formats.
• Troubleshoot assay development and instrument operation issues as they arise.
• Document lab activities in Benchling and revise SOPs; train team members.
• Present experimental results and updates to internal teams.
• Work independently and collaboratively in a multidisciplinary team environment.

Skills

HPLC

qPCR/dPCR

ELISA

Benchling

Education

BS/MS/PhD in Chemistry, Biochemistry, Molecular Biology or related field

Tools

JMP

GraphPad

Empower

Chromeleon

MS Office

Job description

Serif Biomedicines is seeking a Scientist I to join the Analytical Development and Quality Control team in a fast-paced, entrepreneurial setting. The role focuses on building efficient systems for testing samples and delivering data, with method development for nucleic acid cargo and LNP delivery vehicles.

You will mentor colleagues, contribute to platform goals, and communicate results clearly in both oral and written formats, while maintaining rigorous records and SOPs within Benchling.