Protein Characterization Engineer — Biotech R&D Impact

Valerio Therapeutics; Paris; On-site; EUR 43,000 - 50,000; Full time

Benefits offered by this job

Annual bonus

Velib subscription

Health insurance

Job summary

Valerio Therapeutics in France is seeking a protein production specialist to develop, optimize, and validate produced batches while analyzing their biophysical properties. This hands-on role involves data analysis and close collaboration with cross‑functional R&D teams.

You will perform bioanalytical assays (UPLC/HPLC, BLI, HTRF, TSA, DLS, SDS-PAGE), maintain equipment, generate high‑quality data, draft protocols and SOPs, and ensure compliance with internal quality standards.

Qualifications

• Master’s degree, engineering degree, in bioanalysis or biophysicist field.
• 4 to 6 years experience in an analytical, characterization or protein production platform.
• Proficiency in HPLC data generation and interpretation and Bio-layer interferometry.
• Excellent written and oral English communication skills.

Responsibilities

• Perform bioanalytical assays such as UPLC/HPLC, BLI, HTRF, TSA, DLS, SDS-PAGE.
• Maintain equipment and track maintenance.
• Conduct experiments, troubleshoot issues, and generate high-quality data.
• Analyze data and draft summary reports for the team leader.
• Draft protocols, SOPs, and validation reports.
• Ensure compliance with internal quality standards.

Skills

HPLC data interpretation

Bio-layer Interferometry

Data analysis

Analytical problem solving

Education

Master’s degree in bioanalysis or biophysics

Tools

Office software (Outlook, Word, Excel, PowerPoint)

Job description

We are an innovative biotech company specializing in the development of next-generation therapeutics (single-domain antibodies, siRNA, LNP… etc.). Our agile and passionate R&D team works on cutting-edge projects in immunology, oncology, and rare diseases.

Job Summary

We are seeking a candidate who will work in the protein production team to develop, optimize, and validate the quality of the produced batches, but also analyze their biophysical properties. This position involves hands-on laboratory work, data analysis, and close collaboration with cross-functional R&D teams.

Responsibilities:

• Perform bioanalytical assays such as UPLC/HPLC, Bio-layer Interferometry (BLI), Homogeneous time resolved FRET (HTRF), Thermal Shift Assay (TSA), DLS, SDS-PAGE.
• Maintain our equipment in good condition and ensure their maintenance is tracked.
• Conduct laboratory experiments, resolve technical issues, and ensure the generation of high-quality data.
• Analyze and interpret generated datas; draft summary reports and communicate results to the team leader.
• Contribute to the drafting of protocols, standard operating procedures (SOPs), and validation reports.
• Ensure compliance with internal quality standards.

Required Qualifications:

• Master’s degree, engineering degree, in bioanalysis or biophysicist field.
• Proven experience (4 to 6 years) in an analytical, characterization or protein production platform.
• Previous experience in a biotech environment is a plus.
• Proficiency in HPLC data generation and interpretation and Bio-layer interferometry.
• Ability to interpret and present non-clinical data clearly and concisely.
• Strong analytical and problem-solving skills.
• Strong team spirit, flexibility, and ability to work in a cross-functional environment.
• Demonstrated ability to solve problems, prioritize tasks, manage multiple projects simultaneously, and conduct experiments independently within set deadlines.
• Attention to detail and ability to work independently, as part of a multidisciplinary team, and with external partners.
• Excellent written and oral communication skills, including in English.
• Proficiency in office software (Outlook, Word, Excel, PowerPoint).

Why work with us?

• Salary: 43K–50K depending on your profile
• Annual individual performance-based bonus
• 100% coverage of Velib subscription fees
• 60% coverage of health insurance premiums (family plan)
• Exciting projects with significant scientific impact
• Supportive and dynamic work environment
• A close-knit team where you’ll quickly be entrusted with real responsibilities
• Modern facilities, state-of-the-art equipment, and… unlimited coffee