Preclinical Trials & In Vitro Bioactivity Lead

Nūmi®; Paris; Hybride; EUR 90 000 - 130 000; Plein temps

Avantages offerts par ce poste

Competitive salary

Health insurance

Transportation coverage

Lunch coverage

Résumé du poste

Nūmi is an early-stage biotech based in Paris, developing bioactive ingredients for infant nutrition. We seek a Preclinical Trials & In Vitro Bioactivity Lead to design the bioactivity strategy and portfolio, coordinating in-house work with CROs and academic partners to deliver robust data for regulatory dossiers.

Work in a hybrid setup with R&D and external collaborators, guiding study design, data interpretation, and communications with leadership and investors.

Qualifications

• PhD or MSc with significant hands-on experience in cell biology, immunology, nutrition sciences, or related field.
• Strong track record in in vitro bioactivity assay design and interpretation.
• Experience managing CROs and academic partners on preclinical studies.
• Knowledge of regulatory expectations for Novel Food or safety data.

Responsabilités

• Design and oversee the in vitro bioactivity portfolio to support ingredient claims.
• Prioritize assays and manage in-house vs outsourced work with CROs.
• Define preclinical animal study portfolio for regulatory support.
• Coordinate external collaborations with CROs and academic partners.
• Translate results into regulatory dossiers and business narratives.
• Represent Nūmi in external scientific discussions and partnerships.

Connaissances

Bioactivity assays

CRO management

Leadership

Regulatory writing

English communication

Formation

PhD preferred or MSc with significant experience

Outils

GLP standards

Description du poste

About Nūmi

Nūmi is a bioproduction platform harnessing human mammary cells to produce key ingredients with proven health benefits across all stages of life. More specifically, it is the first European cultivated breast milk company aiming to produce human milk constituents to better match the ideal nutrition for babies. We are an early-stage, VC-backed biotech based in the heart of Paris (Hôpital Cochin, Paris 14th) and supported by world‑class investors and scientific partners.

About Nūmi

Nūmi is a bioproduction platform harnessing human mammary cells to produce key ingredients with proven health benefits across all stages of life. More specifically, it is the first European cultivated breast milk company aiming to produce human milk constituents to better match the ideal nutrition for babies. We are an early-stage, VC‑backed biotech based in the heart of Paris (Hôpital Cochin, Paris 14th) and supported by world‑class investors and scientific partners.

Nūmi's Values

Positivity

At Nūmi, we cultivate positivity every day. Our mission drives us to communicate with passion and energy, always keeping the bigger impact in sight. We celebrate quick wins, but never lose track of our ultimate goal.

Excellence

At Nūmi, excellence starts with dedication and a commitment to constant improvement. We embrace challenges as opportunities to learn and push ourselves to deliver high‑quality results. Through effort, attention to detail, and integrity, we grow both individually and collectively as a team.

Team-Work and Pedagogy

At Nūmi, we believe that teamwork makes us stronger. We encourage knowledge‑sharing, open feedback, and mutual respect. Each Nūmiz is here to lift others up, ensuring that the collective succeeds.

Ambition

At Nūmi, we set ambitious goals and challenge ourselves to think big. Nūmi is driven by bold ideas and relentless determination, always aiming for the stars to create real impact.

Why this role matters

Nūmi's ingredients are not commodity products. Each one is designed to deliver a specific, evidence‑backed functional benefit for infant nutrition and beyond. Proving that benefit rigorously through in vitro bioactivity assays and preclinical studies is what turns our ingredients from raw materials into science‑backed nutritional actives.

We are looking for a Preclinical Trials & In Vitro Bioactivity Lead to own the design and delivery of Nūmi's bioactivity strategy. This is a hybrid scientific and program‑management role. You will design the overall bioactivity portfolio, arbitrate what is developed in‑house versus outsourced to CROs and academic partners, own the CRO management relationship, and lead the interpretation and synthesis of results into the regulatory dossier and into commercial narratives.

You will report into a matrix structure with our R&D team, our Reg & QC Implementation Lead and our external academic partners, and you will potentially grow a small in‑house team over time.

Key Responsibilities

Bioactivity Strategy & Portfolio Design

• Define the in vitro bioactivity portfolio required to support Nūmi's ingredient claims : digestion models, gut epithelial barrier, immune cell modulation, gut microbiome / prebiotic activity, brain‑relevant bioactivity, and other functional readouts as the pipeline evolves
• Prioritise which assays are developed in‑house versus outsourced to CROs, based on strategic importance, technical availability and speed
• Define the preclinical animal study portfolio (rodent, piglet models) needed as regulatory support

CRO Management and External Collaboration

• Identify, qualify and manage relationships with contract research organisations (CROs) for outsourced in vitro and in vivo studies
• Own scoping, RFP process, contract negotiation input, study design review, milestone tracking, data quality control and study interpretation with each CRO
• Coordinate with academic partners (organoid platforms, microbiome specialists, infant nutrition academics) to complement our internal capabilities

In‑House Bench Ownership (Selective)

• Design and oversee execution of selected high‑strategic‑value in vitro assays run in‑house
• Coordinate with the R&D team on assay development, protocol qualification and data interpretation

Data Integration into Regulatory Dossier

• Partner with the CMC Lead and Reg & QC Implementation Lead to translate bioactivity and preclinical data into defensible content for the EFSA Novel Food dossier (safety, efficacy, nutritional profile sections)
• Ensure GLP or equivalent standards are respected across the studies feeding the dossier

Scientific Voice and Communication

• Represent Nūmi's science externally at conferences, in academic partnerships and in commercial discussions with strategic partners
• Translate complex bioactivity data into decision‑ready narratives for internal leadership, board and investors

Requirements

Experience & Knowledge

• PhD preferred, or MSc with significant equivalent experience, in cell biology, molecular biology, immunology, nutrition sciences, microbiome sciences or a related field, with 5 to 10 years of hands‑on experience post‑PhD or post‑MSc
• Deep expertise in in vitro bioactivity assay design and interpretation : cell‑based assays, immune cell functional assays, microbiome or prebiotic characterisation
• Proven experience managing external collaborations with CROs and/or academic partners on preclinical or in vitro bioactivity studies. This is a core requirement of the role, not a nice‑to‑have
• Familiarity with preclinical animal study design (rodent, piglet models) sufficient to specify and supervise externally
• Understanding of regulatory expectations for functional and safety data in Novel Food or nutrition‑adjacent dossiers

Leadership & Judgement

• Ability to arbitrate between speed, cost and scientific depth when scoping outsourced work
• Comfortable operating with high autonomy in an early‑stage environment
• Willingness to grow a small in‑house team over time

Communication

• Strong verbal and written communication skills in English, including scientific writing

Bonus

• Prior experience in specialised nutrition, nutraceuticals, infant nutrition, human milk science, HMOs or milk proteins bioactivity
• Familiarity with Novel Food Regulation and its safety and efficacy expectations
• Prior experience in a biotech drug discovery or nutrition R&D environment

Benefits

• Unique opportunity to be one of the first employees at an early‑stage biotech company, shaping the future of infant nutrition.
• Growth opportunities : you will have the opportunity to grow and develop with the company.
• Access to top‑quality facilities, research services and infrastructure.
• Competitive salary, part health insurance coverage, part transportation and lunch coverage.
• Employee‑first mentality, we prioritize the well‑being of our team members, both in terms of their mental and physical health.

Recruitment process

• Initial skills matching and review of your background
• First interview with our cofounder and CTO Eugénie
• A technical case study to assess your understanding of bioactivity portfolio design and CRO management
• A last interview on‑site to meet our cofounder and CEO Eden, part of the team and visit the labs
• 2 to 3 reference calls

Nūmi is committed to building a diverse and inclusive workplace. We welcome applications from people from all walks of life.