Postdoctoral researcher position in Functional Genomics

CERBM; France; Sur place; EUR 30 000 - 45 000; Plein temps

Résumé du poste

A leading research organization in France is seeking a highly motivated postdoctoral researcher for a project aimed at understanding gene regulation and transcriptional control. You will engage in high-throughput screening to identify transcriptional regulators and work within a collaborative research environment. A PhD in a relevant field and experience in sequencing libraries are required. The position starts in March 2026, and applications include a CV and cover letter.

Prestations

International research environment

State-of-the-art facilities

Qualifications

• Recently obtained PhD in genomics, molecular biology or other relevant discipline.
• Strong interest in gene regulation and chromatin biology.
• Proven experience in generating high-throughput sequencing libraries.

Responsabilités

• Characterise a new class of transcriptional regulators.
• Design and execute high-throughput screens in cellular models.
• Further characterize promising hits at the molecular and cellular levels.

Connaissances

High-throughput sequencing libraries generation

Gene regulation interest

Molecular cloning

CRISPR/Cas9 genetic engineering

Cell culture

Formation

PhD in genomics or molecular biology

Outils

Proteomics

Description du poste

Organisation/Company CERBM Research Field Biological sciences » Biology Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Country France Application Deadline 5 Jan 2026 - 00:00 (Europe/Paris) Type of Contract Temporary Job Status Full-time Offer Starting Date 1 Mar 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

We are seeking a highly motivated and enthusiastic individual to join the “ Genomic and epigenomic regulation of cell fate ” research group. Our overall aim is to better understand how cellular identity is determined by macromolecules acting on chromatin such as transcription factors and epigenetic regulators, both in physiological and pathological conditions.

In the context of a project funded by the French Research Agency (ANR), you will characterise a potential new class of transcriptional regulators sensing A/T nucleotide content of target genes. Specifically, you will be in charge of designing and executing high-throughput screens in cellular models using two independent approaches based on proteomics (DNA pulldown/mass spectrometry) or CRISPR/Cas9 perturbation coupled with singe-cell transcriptomics (Perturb-seq). Promising hits identified in these screens will be further characterized at the molecular and cellular levels using genetic engineering, biochemical and phenotypic assays.

The laboratory is part of the Functional Genomics & Cancer department within the Institute of Genetics and Molecular and Cellular Biology ( IGBMC ). You will benefit from an international and diverse scientific environment, as well as state-of-the-art facilities including genomics, bioinformatics, proteomics, microscopy, flow cytometry and cell culture.

Qualifications

• Recently obtained PhD in genomics, molecular biology or other relevant discipline.
• Strong interest in gene regulation and chromatin biology.
• Proven experience in generating high-throughput sequencing libraries (e.g. RNA-seq, ChIP-seq).
• Good handling of standard molecular biology techniques including molecular cloning, pulldown assays, Western-blot analysis.
• Experience in CRISPR/Cas9 genetic engineering (optional, but would be a plus).
• Experience in (stem) cell culture (optional, but would be a plus).
• Experience in preparation of proteomics samples (optional, but would be a plus).

Application procedure

The position is available from March 2026 (starting date to be negotiated with the selected candidate). Interviews are expected mid-January.

Applications including CV (1), cover letter (2), and contact details of at least two referees who are familiar with your scientific work (3). Candidates can also contact the laboratory for additional information regarding the research project.