Postdoctoral Researcher - Microbial Stress & CRISPRi

CNRS; France; Sur place; EUR 42 000 - 56 000; Plein temps

Résumé du poste

CNRS in Paris, within the Epitranscriptional Responses to Antimicrobial Stress team at IBPC, seeks a PhD-level researcher to study post-transcriptional tRNA modifications and their impact on stress tolerance in clinical E. coli strains.

You will combine microbiology, genetics, CRISPRi, comparative genomics, and bioinformatics to identify determinants of strain-to-strain stress responses and contribute to publications.

Qualifications

• PhD in microbiology, bacterial genetics, molecular biology, genomics, or a related field.
• Strong experimental experience in bacterial microbiology.
• Experience in bacterial genetics and strain construction.
• Experience with CRISPRi–based strain libraries.
• Proficiency in standard molecular biology techniques.
• Experience in bacterial genome analysis & comparative genomics.
• Bioinformatics skills for genomic data analysis.
• Data analysis & visualization with R and/or Python.
• Ability to integrate experimental, genomic, and phenotypic data.
• Interest in bacterial stress adaptation and antimicrobial tolerance.
• Experience with clinical E. coli strains is a plus.
• Fluent written/spoken English.

Responsabilités

• Culture and handling of clinical Escherichia coli strains.
• Construct bacterial mutant strains and plasmids.
• Develop phenotypic assays for stress conditions.
• Perform microbiology and molecular biology techniques.
• Analyze bacterial genomes and perform comparative genomics.
• Bioinformatic analysis of genomic data.
• Integrate genomic and phenotypic data.
• Contribute to publications and presentations.

Connaissances

Bacterial microbiology

Bacterial genetics

CRISPRi

Molecular biology

Genomics analysis

Bioinformatics

R/Python data analysis

Clinical E. coli strains

English proficiency

Formation

PhD in microbiology

Outils

CRISPRi tools

Genome analysis tools

Description du poste

CNRS in Paris, within the Epitranscriptional Responses to Antimicrobial Stress team at IBPC, seeks a PhD-level researcher to study post-transcriptional tRNA modifications and their impact on stress tolerance in clinical E. coli strains.

You will combine microbiology, genetics, CRISPRi, comparative genomics, and bioinformatics to identify determinants of strain-to-strain stress responses and contribute to publications.