Postdoc: Molecular Biology & Biochemistry in Spermatogenesis

CNRS - National Center for Scientific Research; France; On-site; EUR 38,000 - 46,000; Full time

Job summary

The CNRS - National Center for Scientific Research invites applications for a two-year postdoctoral position in the Intragenomic Conflict and Evolution – EVOGEN team at the I2BC, Gif-sur-Yvette. The project studies the Paris SR meiotic drive system in Drosophila, focusing on HP1D2 during spermatogenesis and its genomic interactions.

Responsibilities include developing CUT&Tag in testes, TurboID labeling, and generating a HP1D2 knockout line to study phenotypic consequences.

Qualifications

• PhD in biology (genetics, genomics, evolutionary biology, or related fields).
• Strong interest in molecular biology, evolutionary genetics, and genome regulation.
• Solid background in biochemistry (protein-protein interactions) is a strong asset.
• Experience with Drosophila, bioinformatics, or confocal microscopy is advantageous but not required.
• Ability to work independently and collaboratively.
• Initiative and capacity to lead a research project.

Responsibilities

• Characterize binding sites of HP1D2 on the Y chromosome using CUT&Tag in Drosophila testes.
• Identify HP1D2 protein partners using TurboID proximity-labeling in Drosophila testes.
• Characterize phenotypic impact of an HP1D2 knockout; design and generate knockout line; assess effects on spermatogenesis.

Skills

Molecular biology

Evolutionary genetics

Genome regulation

Biochemistry

Drosophila

Bioinformatics

Confocal microscopy

Education

PhD in biology (genetics, genomics, evolutionary biology, or related fields)

Tools

CUT&Tag

TurboID proximity-labeling

Transgenesis

Job description

The CNRS - National Center for Scientific Research invites applications for a two-year postdoctoral position in the Intragenomic Conflict and Evolution – EVOGEN team at the I2BC, Gif-sur-Yvette. The project studies the Paris SR meiotic drive system in Drosophila, focusing on HP1D2 during spermatogenesis and its genomic interactions.

Responsibilities include developing CUT&Tag in testes, TurboID labeling, and generating a HP1D2 knockout line to study phenotypic consequences.