Postdoc: IR Beam Shaping for MALDI‑MSI Sensitivity

CNRS - National Center for Scientific Research; France; In loco; EUR 42.000 - 54.000; Tempo pieno

Descrizione del lavoro

CNRS Department Physique des lasers, atomes et molécules invites applications for a postdoctoral researcher to advance infrared beam transport and post-desolvation of MALDI aggregates. The role combines optomechanical design, beam shaping, and experimental validation within the MALDI3.0 project (2027–2029) across Lille-based partners.

Responsibilities include defining components, shaping the beam, timing control between UV and IR lasers, and evaluating imaging sensitivity on biological tissues.

Competenze

• Postdoctoral researcher in optics/laser physics.
• Experience in laser beam shaping and optical simulations.
• Familiarity with MALDI-MSI or mass spectrometry techniques.

Mansioni

• Transport and shape an infrared beam to enhance post-desolvation of MALDI aggregates.
• Define optomechanical components to direct the IR beam in the spectrometer.
• Shape the beam profile and adjust focusing within the MALDI plume formation zone.
• Optimize the time intervals between the UV desorption/ionization laser and the IR post-desolvation laser.
• Test MALDI-MSI imaging performance on biological tissues.
• Combine modeling with instrumental development and experimental measurements.
• Use CODE V and/or Zemax OpticStudio for simulations and beam transport verification.
• Characterize the beam cross-section with an infrared beam analyzer and verify its propagation to the MALDI plume.

Conoscenze

Team player

Communication and adaptability

English: C1

Strumenti

CODE V

Zemax OpticStudio

Descrizione del lavoro

CNRS Department Physique des lasers, atomes et molécules invites applications for a postdoctoral researcher to advance infrared beam transport and post-desolvation of MALDI aggregates. The role combines optomechanical design, beam shaping, and experimental validation within the MALDI3.0 project (2027–2029) across Lille-based partners.

Responsibilities include defining components, shaping the beam, timing control between UV and IR lasers, and evaluating imaging sensitivity on biological tissues.