Postdoc: Biochemistry & Glycobiology of Bacterial Sulfatases

Cnrs Inc; France; On-site; EUR 42,000 - 66,000; Full time

Job summary

CNRS Institute of Structural Biology in Grenoble invites applications for a temporary researcher position focusing on glycosaminoglycan-targeting sulfatases. The role involves engineering enzymes, characterizing mutants, and reporting results at conferences.

Join the SAGAG group to advance structural biology, enzymology and glycan biology within a vibrant international research environment, located in Grenoble Science Park.

Qualifications

• Expertise in recombinant protein production.
• Expertise in enzymology.
• In-depth knowledge of structural biology.
• In-depth knowledge of glycosaminoglycan (GAG) biology.
• English (written/oral) level B2 minimum.

Responsibilities

• Study the structure and functional properties of a bacterial sulfatase targeting glycosaminoglycans.
• Express and purify recombinant enzymes.
• Perform enzymatic activity assays and determine kinetic parameters.
• Develop protein design approaches to generate mutants with improved enzymatic properties.
• Validate the enzymatic properties of selected mutants.
• Determine the structures of selected mutants using X-ray crystallography.
• Present research findings at scientific congresses and conferences.
• Write activity reports and scientific publications.

Skills

recombinant protein production

enzymology

glycosaminoglycan biology

structural biology

Job description

CNRS Institute of Structural Biology in Grenoble invites applications for a temporary researcher position focusing on glycosaminoglycan-targeting sulfatases. The role involves engineering enzymes, characterizing mutants, and reporting results at conferences.

Join the SAGAG group to advance structural biology, enzymology and glycan biology within a vibrant international research environment, located in Grenoble Science Park.