Population PK/Pharmacometrics Modeler- CDI- H/F

INSTITUT DE RECHERCHE PIERRE FABRE SAS; Pechbusque; Sur place; EUR 70 000 - 90 000; Plein temps

Avantages offerts par ce poste

Profit-sharing

Health insurance

16 days of holidays (RTT)

Public transport participation

Teleworking up to 2 days a week

Résumé du poste

INSTITUT DE RECHERCHE PIERRE FABRE SAS is seeking a Population PK/Pharmacometrics Modeler to join the Pharmacokinetics and Toxicology team in Occitanie, France. This role involves leading pharmacometrics analyses within oncology programs and requires a PhD in a relevant field.

The ideal candidate will have extensive experience in population PK modeling and programming skills in tools like NONMEM and R. Benefits include profit-sharing, health insurance, and teleworking options.

Qualifications

• Minimum 5+ years of experience in population PK modeling.
• Experience in supporting regulatory submissions including model preparation.
• Strong programming skills for data manipulation and analysis.

Responsabilités

• Lead population PK/PD modeling strategies.
• Develop pharmacometrics analyses for oncology programs.
• Mentor colleagues on pharmacometrics methodology.

Connaissances

Population PK modeling

Programming in R or Python

Expertise in NONMEM

Interpersonal skills

Formation

PhD in Pharmaceutical Sciences or related field

Outils

NONMEM

Monolix

Description du poste

About the Company

Pierre Fabre is a leading dermo‑cosmetics and pharmaceutical company located in Occitanie, France.

Position Overview

Population PK/Pharmacometrics Modeler within the Pharmacokinetics and Toxicology team, supporting oncology programs at Langlade site, Oncopole, Toulouse.

Responsibilities

• Lead population PK/PD modeling strategies and translate findings into recommendations for clinical development programs.
• Develop and qualify pharmacometrics analyses with emphasis on population PK/PD modeling and exposure‑response analysis in oncology.
• Drive and coordinate integration of pharmacometrics analyses in the drug development process to mitigate risks early and support data‑driven decision‑making.
• Identify opportunities where pharmacometrics analyses can contribute to a better understanding of pharmacokinetics, pharmacodynamics, safety, and efficacy.
• Serve as lead author and key contributor for pharmacometrics sections of clinical and regulatory documents (briefing books, summaries, responses to Health Authority questions).
• Represent the team at global regulatory hearings/advisory committee meetings and other global regulatory interactions.
• Mentor and guide colleagues on pharmacometrics methodology and contribute to scientific publication.

Qualifications

• PhD in Pharmaceutical Sciences, Pharmacometrics, Biostatistics, Applied Mathematics, or a related quantitative field.
• Minimum 5+ years of hands‑on population PK modeling experience in the pharmaceutical industry.
• Expert‑level proficiency in NONMEM; familiarity with other mixed‑effects modeling tools (Monolix, etc.) is a plus.
• Extensive experience with advanced population PK/PD methodology.
• Strong programming skills in R or Python for data manipulation, exploratory analysis, diagnostics, and visualization.
• Experience in supporting regulatory submissions (IND, NDA/BLA) including preparation of modeling sections and responding to health authorities.
• Excellent interpersonal skills and ability to work in cross‑functional teams.
• Excellent written and verbal skills in English.

Preferred Qualifications

• Proven track record of delivering pharmacometrics analyses that influenced clinical development or regulatory decisions.
• Experience with model‑based meta‑analysis, Bayesian trial design, or novel exposure‑response methods.
• Understanding of oncology drug development is highly desirable.
• Experience modeling multiple therapeutic modalities beyond small molecules (biologics, targeted therapies, ADCs) is a plus.

Benefits

• Incentives, profit‑sharing, and Pierre Fabre shareholding with matching contribution.
• Health and provident insurance.
• 16 days of holidays (RTT) in addition to 25 days of personal holidays.
• Public transport participation.
• Teleworking up to 2 days a week (according to company rules).

Inclusion & Diversity

The company values diversity as a source of fulfillment, social balance and complementarity for its employees, and offers positions open to all, without restriction.