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PhD in molecular neurobiology and stem cells (M/F)

CNRS

France

Sur place

EUR 25 000 - 30 000

Plein temps

Aujourd’hui
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Résumé du poste

A research organization in France is seeking a PhD candidate for a project on olfactory brain plasticity during gestation and maternity. The role involves using various techniques such as immunostaining, imaging, and animal behavior analysis. Candidates should have a background in molecular biology and experience with imaging is preferred. Funding is provided through multiple grants, and this is a full-time temporary position.

Qualifications

  • Candidate should have a background in molecular biology.
  • Experience with imaging preferred.
  • Experience in animal surgery is desired but not mandatory.

Responsabilités

  • Explore mechanisms of neuronal integration during maternity.
  • Use immunostaining and imaging techniques.
  • Conduct AAV manipulation of neural circuits.

Connaissances

Basic molecular biology techniques
Imaging experience
Animal surgery

Formation

PhD candidate
Description du poste

Organisation/Company CNRS Department Institut de génomique fonctionnelle de Lyon Research Field Biological sciences Biological sciences » Biology Researcher Profile First Stage Researcher (R1) Country France Application Deadline 30 Oct 2025 - 23:59 (UTC) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Dec 2025 Is the job funded through the EU Research Framework Programme? Horizon Europe - ERC Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The "Spatio-temporal Logic of Adult Neurogenesis" team is located within UMR 5242, at the Institute of Functional Genomics of Lyon (IGFL). It is a multidisciplinary institute, offering interesting exposure to several system models around common themes related to development, regeneration, evolution, and physiology. One of the institute's strengths is the quality of its single-cell and spatial imaging and transcriptomics platforms.

Our team is supported by funding from the Fondation pour la recherche médicale (FRM), ATIP-AVENIR, and ERC starting grants.

Title: Olfactory Brain Plasticity During Gestation and Maternity

Background

Research over the past three decades has demonstrated that new neurons can be generated in the adult brain and integrate into complex pre-existing circuits. The process of adult neurogenesis is evolutionarily conserved across vertebrates, including fish, amphibians, reptiles, birds, rodents, and primates. It is supported by a small population of undifferentiated cells, called neural stem cells, that persist as embryonic remnants in adult brains. These cells reside in tightly controlled microenvironments called "niches."

Objectives of the PhD project

The gestation and maternity periods in mammals open a window of important brain plasticity. We will explore the mechanisms by which new neurons integrate into the maternal olfactory bulb without disrupting the balance of existing circuits.

Activities

The student will use various techniques to answer the biological question posed:

  • Immunostaining, FISH
  • Confocal and lightsheet imaging techniques
  • AAV manipulation of neural circuits and stereotaxic surgery
  • Cell culture
  • Animal behavior
Skills
  • Basic molecular biology techniques and experience with imaging. Previous experience in animal surgery is desired but not necessary.
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