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A research organization in France is seeking a PhD candidate for a project on olfactory brain plasticity during gestation and maternity. The role involves using various techniques such as immunostaining, imaging, and animal behavior analysis. Candidates should have a background in molecular biology and experience with imaging is preferred. Funding is provided through multiple grants, and this is a full-time temporary position.
Organisation/Company CNRS Department Institut de génomique fonctionnelle de Lyon Research Field Biological sciences Biological sciences » Biology Researcher Profile First Stage Researcher (R1) Country France Application Deadline 30 Oct 2025 - 23:59 (UTC) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Dec 2025 Is the job funded through the EU Research Framework Programme? Horizon Europe - ERC Is the Job related to staff position within a Research Infrastructure? No
The "Spatio-temporal Logic of Adult Neurogenesis" team is located within UMR 5242, at the Institute of Functional Genomics of Lyon (IGFL). It is a multidisciplinary institute, offering interesting exposure to several system models around common themes related to development, regeneration, evolution, and physiology. One of the institute's strengths is the quality of its single-cell and spatial imaging and transcriptomics platforms.
Our team is supported by funding from the Fondation pour la recherche médicale (FRM), ATIP-AVENIR, and ERC starting grants.
Title: Olfactory Brain Plasticity During Gestation and Maternity
Research over the past three decades has demonstrated that new neurons can be generated in the adult brain and integrate into complex pre-existing circuits. The process of adult neurogenesis is evolutionarily conserved across vertebrates, including fish, amphibians, reptiles, birds, rodents, and primates. It is supported by a small population of undifferentiated cells, called neural stem cells, that persist as embryonic remnants in adult brains. These cells reside in tightly controlled microenvironments called "niches."
The gestation and maternity periods in mammals open a window of important brain plasticity. We will explore the mechanisms by which new neurons integrate into the maternal olfactory bulb without disrupting the balance of existing circuits.
The student will use various techniques to answer the biological question posed: