Manufacturing Associate II / III, Cell Culture (Days)

Biogen; Nouvelle-Calédonie; On-site; EUR 29,000 - 42,000; Full time

Benefits offered by this job

Medical Insurance

Dental Insurance

Vision Insurance

Life Insurance

401(k) plan

Employee stock purchase plan

Tuition reimbursement

Paid vacation & holidays

Job summary

Biogen is seeking a Manufacturing Associate to support Upstream cell culture operations at its RTP facility. The role involves aseptic handling, bioreactor prep, media feeds, and in-process testing to ensure product quality in a cGMP environment.

Responsibilities include aseptic inoculations, automation with CIP/SIP, probe calibration, and cross-functional collaboration with MSAT, Quality, and Engineering teams. Shift work and strict SOP adherence are required.

Qualifications

• Bachelor’s degree in STEM or equivalent preferred.
• GxP and GMP familiarity.
• Ability to follow SOPs and shift schedules.

Responsibilities

• Perform inoculation thaws, splits, and pools using aseptic technique with WAVE bags and ITV cans.
• Prepare bioreactors by executing automated CIP/SIP recipes using DeltaV.
• Standardize and calibrate pH and DO probes during bioreactor preparation.
• Perform inoculation of bioreactors across multiple scales.
• Support cell growth operations, including media feeds and process additions.
• Conduct routine sampling and in-process testing to monitor product quality.
• Standardize and maintain laboratory and manufacturing equipment (Vi-Cell Blu/XR, Osmometer, pH meters, RapidPoint BGA, Conductivity meters, Biosafety cabinets, small-scale centrifuges).
• Accurately document activities in accordance with cGMP and SOP requirements.
• Maintain a clean, safe, and compliant manufacturing environment.
• Collaborate cross-functionally with Manufacturing, MSAT, Quality, and Engineering teams.

Skills

Aseptic technique

Cleanroom practices

Documentation

SOP adherence

GxP experience

Shift work

Education

Bachelor’s degree (STEM)

BioWorks Certificate / Associate’s degree

High School Diploma + 0.5–1.5 years experience

Tools

DeltaV

Syncade

Job description

About This Role

Our factories run 24/7 operations. Our manufacturing teams work 12-hour shifts (either Days or Nights) on a 2-2-3 calendar rotation.

• Shift Details: This role follows a 2-2-3 calendar rotation on days (6:00 AM – 6:00 PM ET)
• Internal Shift Details: Black Days rotating schedule

Our Manufacturing Associates perform processing steps and manufacturing support activities in our Drug Substance facility in Research Triangle Park (RTP). These teams are the backbone of our operations – each playing a critical role in delivering our therapies to the patients who need them.

Our teams are organized by the steps in the biomanufacturing process that they operate in; including – Upstream (Cell Culture), Downstream (Purification), and Media & Solution Preparation. Manufacturing Associates perform these critical steps in a clean environment governed by Current Good Manufacturing Practices (cGMP).

This role’s primary focus is on Upstream Cell Culture operations:

• Mammalian cell culture & harvest:
• Work in Shake flasks, WAVE bags, centrifuges, stainless steel bioreactors up to 15,000L
• Performing thaws and splits utilizing Aseptic technique

What You’ll Do

• Perform inoculation thaws, splits, and pools using aseptic technique with WAVE bags and ITV cans
• Prepare bioreactors by executing automated CIP/SIP recipes using DeltaV
• Standardize and calibrate pH and DO probes during bioreactor preparation
• Perform inoculation of bioreactors across multiple scales
• Support cell growth operations, including media feeds and process additions
• Conduct routine sampling and in-process testing to monitor product quality
• Standardize and maintain laboratory and manufacturing equipment, including:
  • Vi-Cell Blu/XR
  • Osmometer
  • pH meters
  • RapidPoint BGA
  • Conductivity meters
  • Biosafety cabinets
  • Small-scale centrifuges
• Accurately document activities in accordance with cGMP and SOP requirements
• Maintain a clean, safe, and compliant manufacturing environment
• Collaborate cross-functionally with Manufacturing, MSAT, Quality, and Engineering teams

Who You Are

You’re driven by a mission to save lives and bring a deep sense of purpose to the work you do. Biomanufacturing is complex, and you thrive in fast-paced environments where learning agility, problem-solving, and adaptability are essential.

Required Skills for a Manufacturing Associate II: $23.56 - $30.77 Pay Range

• The following combination of academic and/or relevant experience may be considered:
  • Bachelor’s degree from an accredited college or university, STEM preferred and 0+ years of direct experience
  • A BioWorks Certificate or associate’s degree, STEM preferred and 0+ years of direct experience
  • A High School Diploma (or equivalent) and at minimum of .5 years of direct experience
• Previous experience in a GxP environment
• Ability to follow SOPs and work effectively on shift schedules if required
• Demonstrated documentation and data integrity skills
• Understanding of aseptic technique and cleanroom practices is preferred

Required Skills for a Manufacturing Associate III: $25.96 - $34.13 Pay Range

• The following combination of academic and/or relevant experience may be considered:
  • Bachelor’s degree from an accredited college or university, STEM preferred and at minimum .5 years of direct experience
  • A BioWorks Certificate or associate’s degree, STEM preferred and at minimum 1 year of direct experience
  • A High School Diploma (or equivalent) and at minimum of 1.5 years of direct experience
• Previous experience in a cGMP environment
• Ability to follow SOPs and work effectively on shift schedules if required
• Demonstrated documentation and data integrity skills
• Knowledge of aseptic technique and cleanroom practices
• Exposure to Delta V, Syncade, or similar systems
• Experience performing bioreactor preparation, inoculation, and monitoring is preferred
• Hands-on experience with mammalian cell culture operations is preferred

Preferred Skills

• Bachelor’s degree in Science, Technology, Engineering and Mathematics (STEM) from an accredited college or university
• Strong communication skills and a team-oriented mindset

Job Level: Entry Level

Additional Information

The base compensation range for this role is: $25.56-$34.13

Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.

In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees’ and their families physical, financial, emotional, social well-being; including, but not limited to:

• Medical, Dental, Vision, & Life insurances
• Fitness & Wellness programs including a fitness reimbursement
• Short- and Long-Term Disability insurance
• A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
• Up to 12 company paid holidays + 3 paid days off for Personal Significance
• 80 hours of sick time per calendar year
• Paid Maternity and Parental Leave benefit
• 401(k) program participation with company matched contributions
• Employee stock purchase plan
• Tuition reimbursement of up to $10,000 per calendar year
• Employee Resource Groups participation

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life‑changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our Biogen.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.