M/F Post-doctoral Position, Biofabrication of functional organoids

EURAXESS Ireland; Compiègne; Hybride; EUR 30 000 - 42 000; Plein temps

Résumé du poste

The CNRS BioFAB research group at the University of Technology of Compiègne invites applications for a PhD-level researcher to advance liver-on-a-chip models within the APOLLO project, funded through national and EU partnerships.

The successful candidate will develop organoid formation protocols, perform immunolabelling, omics and functional assays, supervise Master’s students, present findings at meetings and conferences, and collaborate with industry partners on prototype evaluation.

Qualifications

• PhD in tissue engineering, bioengineering or cell biology.
• Experience in cell culture and organoid production.
• Immunolabelling, PCR; microfluidics would be an asset.
• Fluency in English (written and spoken).
• Ability to work in a team and collaborate with industrial partners.

Responsabilités

• Develop and validate protocols for liver organoid formation in microfluidic devices.
• Characterise reconstructed tissue biologically, mechanically and functionally.
• Study liver-on-a-chip responses to biopharmaceuticals using lab techniques.
• Conduct testing campaigns and evaluate prototypes from partners.
• Draft scientific reports and publications.
• Supervise Master’s students.
• Participate in scientific meetings and conferences.

Description du poste

Organisation/Company CNRS Department Biomécanique et Bioingénierie Research Field Pharmacological sciences Engineering Technology Researcher Profile First Stage Researcher (R1) Application Deadline 25 Sep 2026 - 23:59 (UTC) Country France Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Oct 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

As part of the APOLLO project 'Automated Platform for Organoids, Liver, and Lab On-Chip' led by the industrial partner Fluigent and funded by BPI (Biotherapies and Bioproduction of Innovative Therapies programme), develop biological liver-on-a-chip models suitable for the evaluation of biopharmaceuticals (antibodies, nanobodies, …)

• Develop and validate protocols for the formation of multicellular liver organoids in microfluidic devices (hepatocytes, LSECs, Kupffer cells)
• Characterise the reconstructed tissue: biologically, mechanically and functionally, using the laboratory's various methods or other specialist expertise.
• Study the response of the liver-on-a-chip following exposure to biopharmaceuticals (immunolabelling, omics, functional assays)
• Conduct testing campaigns and evaluate prototypes supplied by partners
• Draft scientific reports and publications
• Supervise Master's students
• Participate in the project's scientific and technical meetings
• Participate in scientific conferences.

The successful candidate will work at the University of Technology of Compiègne within the BMBI laboratory (CNRS UMR 7338) and, more specifically, within the BioFab research area, whose objectives are to contribute fundamental knowledge to tissue engineering and to establish alternative experimental models to animal testing (NAM).
The work will be carried out on the INGESYSBIO meta-platform: Engineering of native or reconstructed biological systems (https://bmbi.utc.fr/recherche/meta-plateformes ): Laboratories L1 and L2, microfluidics and microfabrication platform, histology, immunolabelling, Airyscan confocal microscope, qPCR, and additive manufacturing equipment.
Collaboration with our industrial partners is planned (site visits, hosting engineers at our platforms).

Education: PhD in tissue engineering, bioengineering or cell biology.
Technical skills: experience in cell culture and organoid production, immunolabelling, PCR. Microfluidics would be an asset
Ability to work in a team and collaborate with industrial partners
Project management, scientific writing
Fluency in English (written and spoken)