DOCTORANT_076_MK - H/F

Inserm; Illkirch-Graffenstaden; Hybrid; EUR 42,000 - 54,000; Full time

Job summary

Inserm recherche un(e) chercheur(se) pour un contrat à durée déterminée de 36 mois dans le domaine de la biologie musculaire. Le poste implique l’étude du MTJ et l’analyse du translatome des cellules musculaires développées in vitro, ainsi que l'identification de partenaires protéiques et des mécanismes moléculaires locaux.

Le candidat conduite des approches candidates et non candidantes, présente les résultats et supervise des étudiants Master dans un environnement collaboratif et

Qualifications

• Compétences en communication orale et écrite et capacité à présenter les résultats
• Expérience en travail d'équipe et collaboration multidisciplinaire
• Compétences en génétique des souris: maintenance, génotypage, analyses histologiques et imaging
• Tests physiologiques et phénotypage des fonctions musculaires
• Compétences biochimiques en mass-spectrometry et en NGS

Responsibilities

• Présentation du travail lors des réunions de laboratoire et lors de conférences
• Encadrement d'étudiants Masters
• Participation à des analyses et interprétation des données expérimentales

Skills

Communication skills

Collaborative team spirit

Mouse genetics skills

Physiological tests

Biochemical skills

Mass-spectrometry

NGS

Education

Master degree level

Job description

About the position

Research will be in the field of fundamental skeletal muscle biology and will consist of two complementary scientific axes:(1) investigation of the molecular mechanisms controlling local protein synthesis at the muscle-tendon junction, and (2) transcriptomic characterization of the maturation of skeletal muscle cells generated in vitro.

Desired profile

Main Activities

Myotendinous junction (MTJ) is a mechanical buffer of the skeletal muscle cell and prone site to injury upon exercise. Our lab recently developed a new tool to manipulate the MTJ domain and revealed its local translational program as well as how it rewires after exercise. However, the molecular mechanism by which this special translation program is achieved remains unknown. The student will take both candidate and unbiased approaches to address this problem.

• Use mouse genetics to generate mutants of candidate RNA binding proteins and dissect their phenotype.
• Investigate the local translatome upon mutating RNA binding proteins and identify their binding partners.
• Biochemical pull-down identification of candidate factors using affinity tag fused UTRs.

Associated Activities

• Presentation of the work in lab meetings and conferences. Supervising Master students.

Specific Requirements or Constraints

• Mouse genetics skills: maintenance, genotyping, histological analyses, and imaging
• Physiological tests: various assays for phenotyping muscle function
• Biochemical skills for mass-spectrometry, NGS etc.

Skills/Qualifications

• Communication skills (presentation, writing)
• Collaborative team spirit

Application requirements

Required document(s)

Position characteristics

Offer info

Published on 10/21/2026 Contractuel Catégorie A Fixed-term contract - 36 months Full time Beginner accepted License not required Master degree level MASTER