Senior Scientist, Bivalent Proximity Modality Design

Orion Pharma; Espoo; On-site; EUR 90,000 - 140,000; Full time

Benefits offered by this job

Competitive salary

Health and welfare benefits

Relocation support

Career development opportunities

Job summary

Orion Pharma is seeking a Senior Scientist for the Medicine Design group in Espoo, Finland, focusing on bivalent molecules such as PROTACs and RIPTACs. The role emphasizes designing and optimizing linker architectures, building bRo5 libraries, and advancing multi-parameter optimization to enable long-term excellence in this area.

The candidate will lead multi-disciplinary efforts, utilize computational and ML tools, and contribute to IP strategy while collaborating with internal experts to

Qualifications

• PhD in Chemistry or related field with industry experience.
• Strong background in organic synthesis chemistry, medicinal chemistry and lead optimization.
• Experience with synthesis planning, synthetic methods and analytical tools (NMR, HPLC-MS).
• Demonstrated experience in bivalent molecules, PROTACs, or related modalities.
• Knowledge of DMPK/ADME principles and SAR integration into medicinal chemistry decisions.

Responsibilities

• Design and synthesize novel bivalent proximity modalities (PROTACs, RIPTACs).
• Build and expand diverse bRo5 chemical libraries aligned with project needs.
• Perform multi-step organic synthesis and characterize novel compounds.
• Advance multi-parameter optimization addressing ADMET and developability challenges.
• Contribute to IP strategy in collaboration with internal IP specialists.

Skills

Organic synthesis

Medicinal chemistry

Lead optimization

Synthesis planning

SAR generation

Computational chemistry

Machine-learning-based design

Teamwork

English communication

Education

PhD in Chemistry or related field

Tools

NMR

HPLC-MS

Chromatography tools

Job description

Orion Pharma is seeking a Senior Scientist for the Medicine Design group in Espoo, Finland, focusing on bivalent molecules such as PROTACs and RIPTACs. The role emphasizes designing and optimizing linker architectures, building bRo5 libraries, and advancing multi-parameter optimization to enable long-term excellence in this area.

The candidate will lead multi-disciplinary efforts, utilize computational and ML tools, and contribute to IP strategy while collaborating with internal experts to