Doctoral Researcher / Project Researcher in Molecular Physiology

Laplace Expert Ltd; Kuopio; Hybrid; EUR 29,000 - 31,000; Full time

Job summary

University of Eastern Finland, in the Molecular Physiology group, seeks a Doctoral Researcher to study transcriptional regulation in cardiovascular disease. The role involves CRISPR-engineered hiPSC cardiomyocytes, BioID proteomics, and ChIP-seq, with close collaboration with physiologists.

The three-year appointment starts December 2026 on-site at Kuopio campus, with progression into the Faculty’s Doctoral Programme and potential title change to Doctoral Researcher.

Qualifications

• Master's degree or doctoral-qualifying degree in a relevant discipline.
• Hands-on laboratory experience and ability to work independently.
• Willingness to apply for and join the Faculty's Doctoral Programme.

Responsibilities

• Investigate transcriptional regulation in cardiovascular disease using CRISPR hiPSC cardiomyocyte models.
• Generate CRISPR-mediated loss‑of‑function and knock‑in hiPSC lines and differentiate them into cardiomyocytes.
• Build two- and three-dimensional disease models for mechanistic studies.
• Perform BioID proximity proteomics, ChIP-seq, and gene-expression analyses.
• Analyse data, prepare manuscripts, and present findings.

Skills

Independent research

Scientific writing

Scientific presentation

Research collaboration

Education

Master's degree in a relevant field

Tools

CRISPR

hiPSC culture

Cardiomyocyte differentiation

ChIP-seq

BioID

R

Python

Immunocytochemistry

Immunoblotting

Microscopy

Molecular biology

Job description

Doctoral Researcher / Project Researcher in Molecular Physiology

University of Eastern Finland · Faculty of Health Sciences, A.I. Virtanen Institute, Molecular Physiology research group

Apply by 29 Oct 2026

About This Opportunity

The University of Eastern Finland is recruiting a three-year doctoral-pathway researcher to investigate dysregulated transcription in cardiovascular disease using CRISPR-engineered hiPSC cardiomyocyte models, proximity proteomics and ChIP-seq. Applications close on 29 October 2026 at 23:59 Europe/Helsinki.

The position is part of the Research Council of Finland project “Deciphering and Targeting Dysregulated Transcription in Cardiovascular Disease” in UEF's Molecular Physiology group. The researcher will investigate a transcriptional regulator linked to ageing-associated cardiovascular disease and test ways to understand and therapeutically target its function. Experimental work includes generating CRISPR-mediated loss-of-function and knock-in human induced pluripotent stem-cell lines, differentiating them into cardiomyocytes and building two- and three-dimensional disease models. The project combines BioID proximity proteomics, ChIP-seq, gene-expression analysis, immunocytochemistry, immunoblotting, microscopy, protein biochemistry and molecular biology, followed by testing candidate chemical inhibitors in validated hiPSC-cardiomyocyte models. The researcher will work closely with physiologists to characterize cell phenotypes and will analyse data, prepare manuscripts and present findings. The appointment begins as Project Researcher; after the successful candidate is admitted to the Faculty's Doctoral Programme, the title can change to Doctoral Researcher. The role is full time and onsite at UEF's Kuopio campus.

molecular physiology cardiovascular disease hiPSC cardiomyocytes CRISPR BioID ChIP-seq transcriptional regulation

Level

PhD

Attendance

On-site

Time Commitment

Full-time

Start Date

Dec 31, 2026

Duration

Three years; employment expires 31 December 2029

Reference Code

1235/01.01.03/2026

Field

Molecular Physiology and Cardiovascular Disease

Specialization

Biomedical Sciences

Organization Type

University

Funding & Compensation

Amount EUR 2,560-2,820 / Per Month

Funding Type Salary

Funding Status Paid

Period Per Month

Requirements

Education

MSc degree, or a degree qualifying for doctoral studies in the awarding country, in a relevant discipline from a recognized higher-education institution.

Experience

Hands-on laboratory work and independent research ability are required. Cell culture, molecular-biology methods, live-cell imaging, protein chemistry, gene editing, iPSC-derived models, cardiac physiology and R/Python are advantageous.

Technical Skills

• CRISPR
• hiPSC culture
• Cardiomyocyte differentiation
• 2D and 3D disease models
• BioID
• ChIP-seq
• Gene-expression analysis
• Immunocytochemistry
• Immunoblotting
• Microscopy
• Protein biochemistry
• Molecular biology
• R
• Python

General Skills

• Independent research
• Scientific writing
• Scientific presentation
• Research collaboration

Languages

• English · Not Specified · required

The applicant must not hold a doctoral degree at the call deadline. To become a Doctoral Researcher, the selected candidate must be eligible for postgraduate studies and apply for and be accepted into the Faculty's Doctoral Programme after employment begins.