RUMBA-CM: Reprogramming the Tumor Microenvironment Through Microbiome-Derived Immunomodulatory Molecules (SYG-2024/SAL-GL-711)

Agencia Estatal Consejo Superior de Investigaciones Científicas; España; Presencial; EUR 42.000 - 60.000; Jornada completa

Descripción de la vacante

Agencia Estatal Consejo Superior de Investigaciones Científicas, through the Instituto de Investigaciones Biomédicas Sols-Morreale (IIBM-CSIC-UAM) in Madrid, Spain, seeks a highly motivated researcher to lead a CAM Synergy Project on reprogramming the tumor microenvironment. The role focuses on gut microbiome–immunomodulatory molecules, organoid cultures, and advanced co-culture systems in NSCLC models.

The ideal candidate has a strong molecular biology background, international research

Formación

• Proven ability in molecular biology and in vitro assays.
• Experience with 3D/organoid cultures and NSCLC-related research is advantageous.
• Strong publication record and international collaboration experience are preferred.

Responsabilidades

• Lead the CAM Synergy Project (SYG-2024/SAL-GL-711) in the RUMBA program.
• Coordinate experimental design and data analysis for preclinical validation.
• Collaborate with in vivo and multi-omics teams to advance tumor immunology research.

Conocimientos

Molecular biology

In vitro techniques

Flow cytometry

3D/organoid cultures

Immunology

Herramientas

qPCR

Western blotting

Cell culture

Descripción del empleo

Organisation/Company Agencia Estatal Consejo Superior de Investigaciones Científicas Department Instituto de Investigaciones Biomédicas de Madrid -IIBM- Research Field Biological sciences » Biology Researcher Profile Recognised Researcher (R2) Positions Master Positions Application Deadline 9 Oct 2026 - 23:59 (Europe/Madrid) Country Spain Type of Contract To be defined Job Status Full-time Hours Per Week 35 Offer Starting Date 16 Nov 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The Cancer Stem Cells and Fibroinflammatory Microenvironment Group is looking for a candidate for a CAM Synergy Project

Our group is based at the Instituto de Investigaciones Biomédicas Sols-Morreale (IIBM) - CSIC-UAM in Madrid, Spain, a joint center run by the Consejo Superior de Investigaciones Científicas (CSIC) and the Autonomous University in Madrid (UAM). We are also part of the Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), one of the leading ISCIII-accredited Health Research Institutes in Spain.

The group has recently been awarded a CAM Synergy Project( SYG-2024/SAL-GL-711) funded by the Community of Madrid (CAM). These grants aim to support the development of disruptive, frontier research projects carried out jointly by two research groups affiliated with universities or research institutions within the CAM.

The project, acronym RUMBA, investigates how the gut microbiome of patients with non-small-cell lung cancer (NSCLC) who exhibit exceptional responses to immunotherapy may serve as a source of immunomodulatory molecules capable of reversing T cell exhaustion within the tumor microenvironment. Through aptamer-based screening, multi-omics integration, advanced co-culture and organ-on-chip systems, and preclinical validation in genetically modified mouse models, we aim to identify and assess the impact of these molecules on antitumor immune responses in NSCLC. We will optimize stimulation conditions to maximize immunotherapy efficacy and perform validations in preclinical models. This approach seeks to discover novel drugs to overcome resistance in tumors that are refractory to immunotherapy.

We are looking for a highly motivated and competitive candidate to lead this exciting project.

The ideal candidate should have a highly competitive CV, including several Q1/D1 publications, international research experience, strong proficiency in English, and a solid background in molecular biology and in vitro techniques. Valid certification to work with laboratory animals will be considered an asset. For this position, experience with 3D/organoid cultures, immune cell–tumor cell interactions and co-cultures, flow cytometry, and knowledge of non-small cell lung cancer (NSCLC) is essential. Additional expertise in microbiome research will be positively valued.

We are offering a CSIC-based (M3) funded position for 2 years (with the possibility of extension), with a competitive salary and the opportunity to join a dynamic and productive research team. Start date: Autumn 2026

The candidate should have a highly competitive CV, including several Q1/D1 publications, international research experience, strong proficiency in English, and a solid background in molecular biology and in vitro techniques. Valid certification to work with laboratory atoms will be considered an asset. For this position, experience with 3D/organoid cultures, immune cell–tumor cell interactions and co-cultures, flow cytometry, and knowledge of non-small cell lung cancer (NSCLC) is essential. Additional expertise in microbiome research will be positively valued.

Specific Requirements

Cell culture and processing, including co-culture systems; preparation and treatment of cells with compounds; cytotoxicity assays; application of cellular and molecular biology techniques such as qPCR, Western blotting, RNA, DNA and protein isolation and quantification, and electrophoresis; sample preparation and flow cytometry; reagent preparation; preparation and analysis of samples for microscopy; biochemical and immunohistochemical assays; vector preparation; animal handling; and data presentation using specialized software.

Certification to work with laboratory animals, Functions B and C, is required.

All tasks are part of project SYG-2024/SAL-GL-711, “Reprogramming the Tumor Microenvironment Through Microbiome-Derived Immunomodulatory Molecules (RUMBA-CM).”

Languages ENGLISH Level Good

Research Field Biological sciences » Biology Years of Research Experience 1 - 4

Additional Information

Work Location(s)

Number of offers available 1 Company/Institute Instituto de Investigaciones Biomédicas Sols-Morreale, CSIC-UAM Country Spain State/Province Madrid City Madrid Postal Code 28029 Street Calle Arturo Duperier 4 Geofield