Postdoctoral Researcher in Centrosome Proteostasis and Cell Biology

Centre for Genomic Regulation; Barcelona; On-site; EUR 35,000 - 52,000; Full time

Job summary

The Centre for Genomic Regulation (CRG) in Barcelona, Spain, invites applications for a Postdoctoral Researcher in Centrosome Proteostasis and Cell Biology. The selected candidate will join the Bettencourt-Dias Lab to study turnover of centrosomal proteins across the cell cycle using quantitative proteomics, advanced imaging and cell-based assays.

The role combines proteomics, molecular perturbations and microscopy to uncover fundamental mechanisms of proteostasis with relevance to health and

Qualifications

• PhD in Cell Biology or related field.
• Experience in proteomics or cell biology research.
• Experience with CRISPR and gene editing techniques.
• Experience with fluorescence microscopy and imaging workflows.

Responsibilities

• Develop and apply experimental approaches to measure turnover of centrosome components and their dynamics across the cell cycle.
• Contribute to centrosome enrichment and quantitative proteomics workflows in collaboration with CRG core facilities.
• Investigate regulators of protein turnover and centriole integrity using molecular perturbations and biochemical and imaging assays.

Skills

Cell biology

CRISPR / gene editing

RNAi / perturbation

Fluorescence microscopy

Education

PhD in Cell Biology

Job description

You are here:Home > Postdoctoral Researcher in Centrosome Proteostasis and Cell Biology

Postdoctoral Researcher in Centrosome Proteostasis and Cell Biology

Postdoctoral Researcher in Centrosome Proteostasis and Cell Biology

The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

The Cell Division and Organelle Biology lab is recruiting a highly motivated postdoctoral researcher to investigate how centrioles and centrosomes maintain their structural integrity throughout the cell cycle. The successful candidate will contribute to the CENTROSTASIS project, focusing on the turnover of centrosomal proteins and the molecular pathways that regulate organelle maintenance. The role combines quantitative proteomics, cell-based assays and advanced microscopy to uncover fundamental mechanisms of proteostasis and their relevance to health and disease.

Key responsibilities:

• Develop and apply experimental approaches to measure turnover of centrosome components and their dynamics across the cell cycle.
• Contribute to centrosome enrichment and quantitative proteomics workflows in collaboration with CRG core facilities.
• Investigate regulators of protein turnover and centriole integrity using molecular perturbations and biochemical and imaging assays.

About the lab

The Bettencourt-Dias Lab investigates cell division and organelle biology, with particular emphasis on centrosomes and cilia. The team uses cell biology, high-resolution microscopy, proteomics and molecular approaches to understand how centrioles are assembled, maintained and eliminated in heath and disease, and how these processes evolved in eukaryotes.

Whom would we like to hire?

Professional experience

Must Have

• Experience in cell biology, biochemistry, molecular biology or proteomics
• Experience in cell culture and gene editing (CRISPR, lentivirus, etc.)
• Experience in cell perturbation (RNAi, drug inhibitors, etc.)
• Experience in fluorescence microscopy

Desirable but not required/ Nice to have

• Experience in cell cycle regulation, centrosome biology or protein turnover
• Experience with SNAP-tag pulse-chase labelling
• Previous knowledge of expansion microscopy
• Skilled in quantitative image analysis (ImageJ/FIJI, Imaris, or similar)

Education and training

• A PhD in Cell Biology (or related disciplines), completed by the position start date

Languages

Competences

• Highly developed organizational skills
• Careful experiment planning, and rigor in scientific pursuits
• Capacity to work in a highly collaborative environment
• Great communication skills of your scientific results

The Offer - Working Conditions

• Contract duration: Technical and scientific activities contract linked to the project (estimated duration 3 years)
• Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section .

We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.

The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.

Selection Process

• Pre-selection: The pre-selection process will be based on qualifications and expertise reflected on the candidates CVS. It will be merit-based.
• Interview: Preselected candidates will be interviewed by the Hiring Manager of the position and a selection panel if required.
• Offer Letter: Once the successful candidate is identified the People department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.

Deadline

Please submit your application by November 19, 2026.

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