Postdoc - Evolution Of Genome Regulation

Centre For Genomic Regulation; Barcelona; On-site; EUR 40,000 - 52,000; Full time

Job summary

The Centre for Genomic Regulation (CRG) in Barcelona invites applications for a Postdoctoral researcher to study the evolution of chromatin states and regulators across diverse eukaryotes. The project combines chromatin proteomics, epigenetic drug treatments, and genetic perturbation to explore genome regulation.

Join an interdisciplinary team working on the CELL-SYSTEMATICS ERC project, collaborating across developmental, computational, evolutionary and molecular biology to understand cell type

Qualifications

• Experience in chromatin biology (ChIP-seq, ATAC, etc).
• Experience in basic molecular biology protocols.
• Basic experience in bioinformatics (UNIX environments, R/Python, etc).

Responsibilities

• Investigate the evolution of chromatin states and regulators across diverse eukaryotes.
• Combine chromatin proteomics, epigenetic drug treatments, and genetic perturbation of candidate chromatin readers-effectors.
• Collaborate within an interdisciplinary team to advance the CELL-SYSTEMATICS ERC project.

Skills

Chromatin biology

Molecular biology

Bioinformatics

Education

PhD in Biology

Tools

UNIX

R

Python

Job description

Postdoc - Evolution of Genome Regulation

The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

We are seeking a highly motivated postdoctoral researcher to investigate the evolution of chromatin states and regulators across eukaryotes. The successful candidate will combine chromatin proteomics, epigenetic drug treatments, and genetic perturbation of candidate chromatin readers-effectors in diverse species. We welcome enthusiastic applicants with a broad interest in evolutionary biology, gene regulation, and/or chromatin biology, and with a solid background in functional genomics.

The work will be part of our ERC-funded project CELL-SYSTEMATICS, which aims at understanding how animal cell type diversity originated and evolve. The candidate will be part of a highly interdisciplinary team that includes developmental, computational, evolutionary and molecular biologists.

References

Navarrete, C. et al. Diversity and evolution of chromatin regulatory states across eukaryotes. Nat Genet 58, 2134–2140 (2026).

Grau-Bové, X. et al. A phylogenetic and proteomic reconstruction of eukaryotic chromatin evolution. Nat Ecol Evol 6, 1007–1023 (2022).

About the lab

The Sebé-Pedrós lab studies the evolution of cell type programs and genome regulation, combining single-cell genomics, chromatin profiling, and comparative genomics methods in a phylogenetically diverse array of eukaryotes. For more details about the lab, visit the lab website: https://www.sebepedroslab.org/

Whom would we like to hire?

Professional experience

Must Have

• Experience in chromatin biology (ChIP-seq, ATAC, etc)
• Experience in basic molecular biology protocols
• Basic experience in bioinformatics (UNIX environments, R/Python, etc.)

Desirable but not required/ Nice to have

• Experience in genetic tools in non-model species
• Experience in molecular phylogenetics and comparative genomics

Education and training

• A PhD in Biology (or related disciplines)

Languages

• Highly developed organization and coordination skills
• Dedication, motivation, and rigor in scientific pursuits
• Capacity to work both independently and as part of a team

The Offer – Working Conditions

• Contract duration: Technical and scientific activities contract linked to the project (estimated duration 2 yesars)
• Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section .

We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.

The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.