Senior PKPD Modeling Scientist - Translational Lead

Novo Nordisk A/S; Denmark; Remote; DKK 651,000 - 957,000; Full time

Job summary

Novo Nordisk A/S in Måløv, Denmark, seeks a Senior PKPD Modeling Scientist for a maternity cover. You will contribute to translational PK/PD, design preclinical studies, and build models to inform first-in-human decisions.

You will collaborate across in vivo and clinical teams, use tools like NONMEM and R, and communicate with regulators as needed. The role offers exposure to cutting-edge translational science and the chance to impact patient outcomes during a defined period.

Qualifications

• A Ph.D. within Pharmaceutical, Medical, Physics, Mathematical or Engineering sciences (or equivalent pharmaceutical industry experience)
• 3-5 years of relevant post-PhD experience in pharma/biotech
• Strong understanding of PKPD (and ideally PBPK) theory, modelling methodology, data interpretation and translational science
• Experience modelling biological or other natural processes using mechanistic and/or combined mechanistic and empirical models
• Experience with pharmacokinetic and modelling software (e.g. Phoenix WinNonlin/NLME, NONMEM or equivalent) as well as data processing tools (e.g. R, Python, Matlab)
• General digital literacy across generative AI platforms such as ChatGPT and Copilot is preferred
• Excellent communication and stakeholder management skills, ability to collaborate in cross-functional teams

Responsibilities

• Set direction for translational PK and PK/PD screening strategy with stakeholders
• Design preclinical PK/PKPD studies and interpret/report data
• Build mathematical models and simulate human PK/PD up to first-in-human studies
• Guide projects on preclinical study design, dose setting for toxicity studies, and early clinical dose-setting and trial design
• Interact with regulatory authorities and contribute to regulatory documents (IND/IMPD/NDA)
• Maintain state-of-the-art PK/PD competencies and innovate across the R&D value chain

Skills

PKPD theory

PBPK

Mathematical modelling

Translational science

Drug development

R/Python/Matlab scripting

Education

PhD in Pharmaceutical/Medical/Physics/Math/Engineering

Tools

Phoenix WinNonlin

NLME

NONMEM

R

Python

Matlab

Job description

Novo Nordisk A/S in Måløv, Denmark, seeks a Senior PKPD Modeling Scientist for a maternity cover. You will contribute to translational PK/PD, design preclinical studies, and build models to inform first-in-human decisions.

You will collaborate across in vivo and clinical teams, use tools like NONMEM and R, and communicate with regulators as needed. The role offers exposure to cutting-edge translational science and the chance to impact patient outcomes during a defined period.