Pharmacokineticist, PK/PD Modelling & Simulation

H. Lundbeck A/S; København; On-site; DKK 786,000 - 1,081,300; Full time

Job summary

H. Lundbeck A/S in Copenhagen seeks an expert in pharmacology to guide drug discovery through quantitative systems pharmacology insights. You will evaluate new targets, design data requirements, and collaborate with cross-functional teams, translating complex modelling results into actionable strategies.

Ideal candidates hold a BS/MS/PhD and have a strong background in QSP and mechanistic modelling. Experience with relevant modelling tools and a collaborative, scientifically curious mindset are essential for this pivotal role.

Qualifications

• 4–6 years of industry experience in pharmacology or related fields.
• Experience with QSP and mechanistic modelling applications.
• Knowledge of modelling tools relevant to pharmacokinetics.

Responsibilities

• Evaluate feasibility of new targets using quantitative systems pharmacology.
• Design model-informed strategies to assess new target hypotheses.
• Apply PK/PD and PBPK modelling to support decision-making.

Skills

Quantitative systems pharmacology

Mechanistic modelling

Strong communication skills

Collaboration

Education

BS/MS/PhD in pharmacology or related discipline

Tools

NONMEM

R

MATLAB

Gastro-Plus

Job description

Your new role

Step into a pivotal role where your ‘model driven’ insights will guide the strategic direction of our drug discovery and early development projects.

Responsibilities

• Be responsible for evaluating the feasibility of new targets and modalities using quantitative systems pharmacology (QSP) and mechanistic modelling approaches.
• Define data requirements and design model-informed strategies to assess new target hypotheses.
• Apply mechanistic, PK/PD, and PBPK modelling to support candidate selection and first-in-human dose predictions as well as back‑translation of early clinical data.
• Contribute to translational modelling activities bridging preclinical and clinical data.
• Collaborate closely with cross‑functional teams to integrate modelling insights into project strategies.
• Represent the department in discovery project teams, providing modelling and simulation input to support decision‑making from target validation to early clinical development.

Your future team

YOU’ll be part of the Experimental Medicine organization – a dynamic group that bridges research and development, with a focus on biomarkers, quantitative pharmacology, and translational science. Based at our headquarters in Valby, Copenhagen, you’ll collaborate with passionate scientists dedicated to improving brain health.

What you bring to the team

• BS or MS (with at least 4–6 years of industry experience) or PhD in pharmacology, pharmacokinetics, pharmaceutical science, bioengineering, chemical engineering, systems biology, or related discipline.
• Experience with QSP and mechanistic modelling applied to early discovery and feasibility evaluation.
• Knowledge of PK/PD and PBPK modelling tools (e.g., NONMEM, R, MATLAB, Gastro‑Plus or other similar software such as Simcyp, PK‑Sim).
• A physiological and mechanistic understanding that facilitates strong collaboration across research and clinical teams.
• Strong communication skills and the ability to translate complex modelling results into actionable insights.
• Self‑motivated, collaborative, and scientifically curious mindset.

Benefits

Annual Base Salary Range: 786 000.00 - 1 081 300.00 DKK gross.