Senior Pharmacometrician - Translational PK/PD & MIDD Lead

Ascendis Pharma; Hellerup; On-site; DKK 1,000,000 - 1,400,000; Full time

Job summary

Ascendis Pharma, a global biopharmaceutical company, seeks a hands-on Specialist/Senior Specialist Pharmacometrician to drive model-informed drug development across translational and clinical programs. You will influence trial design, dose selection and regulatory strategies, collaborating with cross-functional teams and external partners in a dynamic, fast-paced environment.

You will report to the Senior Director and Head of Pharmacometrics in Hellerup, Denmark, with opportunities to contribute

Qualifications

• PhD, MSc, or equivalent qualification in a quantitative discipline.
• Experience with PK/PD modeling and model-informed drug development.
• Hands-on experience with NONMEM and R for population PK/PD modeling and simulations.
• Strong programming skills and ability to document and report analyses for submissions.
• Experience with translational and clinical-stage analyses including population PK, PK/PD, exposure–response, dose selection, and trial design questions.
• Industrial experience supporting regulatory submissions and familiarity with FDA/EMA/ICH expectations.
• Familiarity with LaTeX, Git and reproducible reporting workflows; exposure to ML/AI in pharmacometrics is a plus.

Responsibilities

• Develop model-informed drug development strategies for translational and clinical-stage projects.
• Shape regulatory strategy and represent pharmacometrics in global health authority interactions.
• Inform dose selection, trial design, regulatory strategy, and lifecycle decisions via PK/PD modeling and simulations.
• Translate quantitative results into clear recommendations to teams and management.
• Plan, document and report pharmacometric analyses in line with internal quality standards and submission requirements.
• Strengthen departmental methods and capabilities through peer reviews and knowledge sharing.

Skills

PK/PD modeling

Programming skills

Translational PK/PD analyses

Education

PhD or MSc in a quantitative field (pharmacometrics, pharmacokinetics, pharmaceutical sciences, mathematics, engineering)

Tools

NONMEM

R

LaTeX

Git

Job description

Ascendis Pharma, a global biopharmaceutical company, seeks a hands-on Specialist/Senior Specialist Pharmacometrician to drive model-informed drug development across translational and clinical programs. You will influence trial design, dose selection and regulatory strategies, collaborating with cross-functional teams and external partners in a dynamic, fast-paced environment.

You will report to the Senior Director and Head of Pharmacometrics in Hellerup, Denmark, with opportunities to contribute