Senior Pharmacometrician — Model‑Informed Drug Development

Ascendis Pharma A/S; Gentofte Kommune; Remote; DKK 900,000 - 1,300,000; Full time

Job summary

Ascendis Pharma is seeking a hands-on Specialist/Senior Specialist Pharmacometrician to lead model-informed drug development across translational and clinical programs. You will apply PK/PD modeling, simulation, and exposure–response analyses to inform dose selection, trial design, and regulatory strategies.

The role offers broad ownership, cross-functional collaboration with global teams, and the opportunity to translate quantitative insights into actionable recommendations.

Qualifications

• PhD or MSc in pharmacometrics, pharmaceutical sciences, pharmacokinetics, mathematics or related quantitative discipline.
• Hands-on experience with PK/PD modeling and model-informed drug development.
• Experience with regulatory submissions is desirable.

Responsibilities

• Develop model-informed drug development strategies for translational and clinical-stage projects.
• Shape regulatory strategy and represent pharmacometrics in global health authority interactions.
• Inform dose selection, trial design, regulatory strategy, and lifecycle decisions via PK/PD modeling and simulations.
• Translate quantitative results into clear recommendations to teams and external partners.
• Plan, document and report analyses to internal quality standards and submission requirements.
• Strengthen methods and reporting capabilities within the department.

Skills

NONMEM

R

Pharmacometric analyses

Education

PhD in pharmacometrics or related quantitative field

MSc in pharmacometrics or related quantitative field

Tools

LaTeX

Git

Job description

Ascendis Pharma is seeking a hands-on Specialist/Senior Specialist Pharmacometrician to lead model-informed drug development across translational and clinical programs. You will apply PK/PD modeling, simulation, and exposure–response analyses to inform dose selection, trial design, and regulatory strategies.

The role offers broad ownership, cross-functional collaboration with global teams, and the opportunity to translate quantitative insights into actionable recommendations.