PhD Scholarship: 3D Cochlear Histopathology in Ageing

DTU - Technical University of Denmark; Kongens Lyngby; On-site; DKK 384,000 - 456,000; Full time

Job summary

DTU Health Tech invites applications for a 3-year PhD position to investigate the spatial and temporal relationships between vascular and sensorineural pathology in the cochlea, using cutting-edge 3D microscopy and image analysis in rodent models.

The project focuses on developing preclinical immunolabelling and light-sheet imaging pipelines to study the cochlea, enabling assessment of therapeutic responses and advancing understanding of ageing and age-related diseases.

Qualifications

• Hands-on experience with laboratory rodents in a research setting.
• Practical experience with immunofluorescent tissue labelling and optimization of tissue-processing protocols.
• Experience acquiring and evaluating fluorescence microscopy data.
• Aptitude for quantitative analysis through scripting, image analysis, or statistics.
• Strong interest in inner-ear pathology and ability to pursue research questions independently.
• Ability to handle delicate preparations meticulously and document protocols rigorously.
• Strong written and spoken English; ability to work in a collaborative, interdisciplinary environment.

Responsibilities

• Design and carry out experimental studies in rodent models of hearing loss and systemic disease.
• Develop and validate tissue clearing and whole-organ immunolabelling protocols for the cochlea.
• Acquire light-sheet fluorescence microscopy datasets from intact cochleae.
• Develop quantitative measures of cochlear pathology and contribute to image-analysis pipelines for the data.
• Interpret findings in relation to auditory function and disease markers.
• Publish scientific papers, present at international conferences, and contribute to teaching and supervision at DTU.

Skills

Rodent handling

Immunofluorescent labeling

Fluorescence microscopy

Image analysis

Quantitative scripting

English proficiency

Interdisciplinary collaboration

Tools

Light-sheet microscopy

Immunolabelling protocols

Tissue clearing

Job description

DTU Health Tech invites applications for a 3-year PhD position to investigate the spatial and temporal relationships between vascular and sensorineural pathology in the cochlea, using cutting-edge 3D microscopy and image analysis in rodent models.

The project focuses on developing preclinical immunolabelling and light-sheet imaging pipelines to study the cochlea, enabling assessment of therapeutic responses and advancing understanding of ageing and age-related diseases.