PhD: 3D Cochlear Histopathology & Ageing Research

Technical University of Denmark (DTU); Denmark; On-site; DKK 320,000 - 420,000; Full time

Job summary

The Technical University of Denmark (DTU) invites applications for a 3-year PhD position in the Centre for Auditory Neuroscience within the Hearing Systems section at DTU Health Tech. The project explores vascular and sensorineural pathology in the cochlea using cutting-edge 3D microscopy and image analysis.

You will develop immunolabelling and light-sheet imaging pipelines in rodent models, enabling detailed study of ageing- and disease-related cochlear changes and contributing to new tools for

Qualifications

• Two-year master’s degree (120 ECTS) or equivalent in neuroscience, medicine, biomedicine, veterinary medicine, biomedical engineering, molecular biology, or a related field.
• Hands-on experience with laboratory rodents in a research setting.
• Practical experience with immunofluorescent tissue labelling and optimization of tissue-processing protocols.
• Experience acquiring and evaluating fluorescence microscopy data.
• Demonstrated aptitude for quantitative analysis through scripting, image analysis, or statistics.
• Strong interest in inner-ear pathology and ability to pursue research questions independently.
• Ability to handle delicate preparations meticulously and document experimental protocols rigorously.
• Strong written and spoken English and ability to work in a collaborative, interdisciplinary environment.

Responsibilities

• Design and conduct experimental studies in rodent models of hearing loss and systemic disease.
• Develop and validate tissue clearing and whole-organ immunolabelling protocols for the cochlea.
• Acquire light-sheet fluorescence microscopy datasets from intact cochleae.
• Develop quantitative measures of cochlear pathology and contribute to image-analysis pipelines.
• Interpret findings in relation to auditory function and markers of metabolic and neurodegenerative disease.
• Publish papers, present at international conferences, and contribute to teaching and supervision at DTU.

Skills

Rodent handling

Immunofluorescent labelling

Fluorescence microscopy data

Quantitative analysis

Interest in inner-ear pathology

Meticulous handling & documentation

English proficiency

Education

Master’s degree (120 ECTS) in neuroscience, medicine, biomedicine, veterinary medicine, biomedical engineering, molecular biology or related field

Tools

Tissue clearing

Light-sheet microscopy

Image analysis

Job description

The Technical University of Denmark (DTU) invites applications for a 3-year PhD position in the Centre for Auditory Neuroscience within the Hearing Systems section at DTU Health Tech. The project explores vascular and sensorineural pathology in the cochlea using cutting-edge 3D microscopy and image analysis.

You will develop immunolabelling and light-sheet imaging pipelines in rodent models, enabling detailed study of ageing- and disease-related cochlear changes and contributing to new tools for