(Senior) Principal Scientist - siRNA expert DMPK

Boehringer Ingelheim; Biberach an der Riß; Sur place; EUR 140 000 - 190 000; Plein temps

Avantages offerts par ce poste

Comprehensive benefits

Wellbeing program

Salary transparency in recruitment

Résumé du poste

Boehringer Ingelheim seeks a Principal or Senior Principal Scientist to lead DMPK efforts for siRNA therapeutics in its Biberach site. You will guide pharmacokinetics, tissue disposition, and translational strategies across discovery programs, while collaborating with multidisciplinary teams to advance candidates toward clinical development.

You will supervise in vivo PK studies and help shape innovative experimental approaches, representing the company in scientific networks and partnerships.

Qualifications

• PhD in pharmacokinetics, drug metabolism, pharmacology, biology, pharmaceutical sciences, or related discipline.
• Deep knowledge of DMPK, phys-chem profiling and formulation principles with proven siRNA therapeutics expertise.
• Extensive pharma industry experience translating preclinical findings into clinical development.
• Proven experience in design, interpretation and supervision of in vivo PK studies for siRNA therapeutics.
• Excellent literature awareness and an established scientific network in the siRNA field.
• Strong communication and ability to collaborate in international cross-functional teams.

Responsabilités

• Provide scientific leadership in DMPK for siRNA therapeutics across discovery programs.
• Lead optimization, candidate selection, and translational strategies to drive drug discovery success.
• Define screening strategies with focus on in vitro ADME, in vivo PK, and PK/PD for tissue targeting and safety.
• Interpret and communicate DMPK strategies to stakeholders in meetings and studies.
• Supervise in vivo pharmacokinetic studies and coordinate DMPK profiling activities.
• Contribute to development and application of innovative experimental and data analysis approaches.

Connaissances

DMPK expertise

Pharmacokinetics

In vivo PK studies

Cross-functional collaboration

Leadership experience

Formation

PhD in pharmacokinetics/drug metabolism/pharmacology

Outils

In vivo PK platforms

Description du poste

Help shape the future of siRNA therapeutics by translating cutting-edge DMPK science into impactful drug discovery strategies. In your new role, you will provide scientific leadership, work within multidisciplinary project teams, and influence key decisions from lead optimization to clinical translation. Join us to advance innovative research and accelerate the translation of siRNA therapies from discovery to patients. This position can be filled either as Principal Scientist or Senior Principal Scientist. Discover our Biberach site: xplorebiberach.com

Tasks & responsibilities

• As a recognized scientific expert in DMPK for siRNA therapeutics, you will provide scientific guidance and innovative solutions to pharmacokinetic and tissue disposition challenges across discovery research programs
• Furthermore, you will contribute to multiple multidisciplinary project teams by lead optimization, candidate selection, and translational strategies, thereby driving the success of siRNA-based drug discovery programs
• You will define and advance screening strategies with a focus on in vitro ADME, in vivo PK, and PK/PD to deepen the understanding of siRNA disposition, tissue targeting, efficacy, and safety, as well as coordinate DDS activities
• In research teams and stakeholder meetings, you will interpret, communicate, and influence DMPK strategies and key project decisions through scientific expertise
• The role will include the supervision of in vivo pharmacokinetic studies and the planning and coordination of relevant DMPK profiling activities
• Moreover, you will contribute to the development and application of innovative experimental and data analysis approaches to advance siRNA and oligonucleotide research

Additional tasks for the Senior Principal Scientist role:

• You will shape our siRNA strategy within the company while mentoring scientists and defining scientific best practices
• In addition, you will develop and implement new strategies in international projects and initiatives to continuously improve workflows and interfaces and represent the company's delivery science externally in scientific networks, conferences and partnering discussions

Requirements

• PhD (or equivalent) in pharmacokinetics, drug metabolism, pharmacology, biology, pharmaceutical sciences, or related discipline
• In-depth knowledge of DMPK, phys.-chem. profiling and formulation principles and proven track record in siRNA therapeutics
• Several years of pharmaceutical industry experience in drug discovery of siRNA, with demonstrated success in translating preclinical findings into clinical development
• Proven experience in the design, interpretation and ideally also supervision of in vivo PK studies of siRNA therapeutics
• Excellent overview of scientific literature in the siRNA field as well as an already established scientific network
• Strong communication and interpersonal skills, with the ability to collaborate effectively in international cross-functional teams and convey complex scientific concepts to diverse stakeholders

Additional requirements for the Senior Principal Scientist role:

• Longterm professional experience within the pharmaceutical industry, including leadership of complex, cross-functional drug discovery projects and platform initiatives, and communication to senior leadership forum
• Recognized scientific standing in the siRNA community, demonstrated by publications, patents, invited talks or successful external collaborations

Start date: asap

As part of our commitment to transparency and fairness, salary information will be shared during the recruitment process. We also offer a comprehensive benefits and wellbeing package.

The job posting is presumably online until October 15th, 2026.

We reserve the right to take the posting offline beforehand.

Applications from persons with severe disabilities are warmly welcomed. In cases of equal qualifications, such applicants will be given preferential consideration in the selection process.

Our Company

Boehringer Ingelheim is a biopharmaceutical company active in both human and animal health. As one of the industry's top investors in research and development, the company focuses on developing innovative therapies that can improve and extend lives in areas of high unmet medical need. Independent since its foundation in 1885, Boehringer takes a long-term perspective, embedding sustainability along the entire value chain. Our approximately 54,300 employees serve over 130 markets to build a healthier and more sustainable tomorrow. Learn more at www.boehringer-ingelheim.com.

Why Boehringer Ingelheim?

With us, you can develop your own path in a company with a culture that knows our differences are our strengths - and break new ground in the drive to make millions of lives better.

Here, your development is our priority. Supporting you to build a career as part of a workplace that is independent, authentic and bold, while tackling challenging work in a respectful and friendly environment where everyone is valued and welcomed.

Alongside, you have access to programs and groups that ensure your health and wellbeing are looked after - as we make major investments to drive global accessibility to healthcare. By being part of a team that is constantly innovating, you'll be helping to transform lives for generations.

Want to learn more? Visit https://www.boehringer-ingelheim.com