Research Scientist - Spatial Omics Technology Development

embl; Heidelberg; Vor Ort; EUR 49.000 - 55.000; Vollzeit

Zusammenfassung

EMBL's GenTechDev Open Lab develops open spatial multiomics technologies and standardizes workflows for dissemination across EMBL and partner institutes in Heidelberg. You will act as a bridge between developers and users, translating cutting-edge spatial omics into reproducible protocols.

You will collaborate with international teams, design pilot studies, and contribute to publications while training researchers to adopt complex workflows.

Qualifikationen

• PhD or equivalent with strong background in life sciences, engineering, genomics, or chemistry.
• Experience developing or applying advanced molecular biology, genomics or imaging methods.
• Excellent organizational and communication skills; able to work independently and in teams.
• Fluency in written and spoken English is required.

Aufgaben

• Develop, optimize and standardize padlock probe in situ sequencing workflows.
• Integrate spatial transcriptomics with multiplexed protein imaging and other modalities.
• Create SOPs, validated reagents, and detailed documentation.
• Design pilot experiments and perform technology development.
• Organize day-to-day work to meet long-term milestones and train users.
• Collaborate with EMBL facilities and partner institutes; present results.

Kenntnisse

Method development mindset

Independent and collaborative work

Excellent organizational skills

Excellent communication skills

Fluency in English

Experience with molecular biology/imab

Microscopy experience

Ausbildung

PhD in life sciences or engineering

University Degree with relevant experience

Tools

Padlock probes

In situ sequencing

MERFISH

seqFISH

Jobbeschreibung

EMBL is Europe's leading laboratory for the life sciences and a pioneer in the development of transformative technologies that enable new biological discoveries . The Genomic Technology Development (GenTechDev) Open Lab develops and disseminates next-generation spatial omics technologies combining molecular biology, microscopy, chemistry and automation. Working closely with internal partners at EMBL and external groups and facilities across the MULTI-SPACE initiative and Health + Life Science Alliance Heidelberg Mannheim . GenTechDev develops open-source technologies that complement commercial spatial omics platforms and makes them broadly accessible to researchers.

We are seeking an enthusiastic Postdoctoral level Staff Scientist to help translate cutting-edge spatial transcriptomics and multimodal imaging technologies into robust, standardized workflows for the MULTI-SPACE initiative.

Your role

You will join the GenTechDev Open Lab and work closely with the groups of Sinem Saka , Eileen Furlong and Karsten Rippe (DKFZ), together with collaborators across EMBL, BioQuant, DKFZ, Heidelberg University and Heidelberg University Hospital.

You will act as a bridge between technology developers and users, transforming emerging spatial omics methods into standardized, reproducible workflows and supporting collaborative research projects.

Your responsibilities

• Develop, optimize and standardize padlock probe-based in situ sequencing workflows
• Establish multimodal protocols integrating spatial transcriptomics with multiplexed protein imaging, DNA-FISH, perturbation screening and other imaging/omics modalities
• Develop SOPs, validated reagent resources and documentation
• Design and perform technology development and pilot experiments
• Set priorities and organize your day-to-day work to efficiently reach the long-term milestones
• Support collaborative user projects and technology adoption
• Organize practical training courses and workshops
• Contribute to workflow automation and scalability
• Collaborate with EMBL core facilities and partner institutes
• Present results and contribute to scientific publications

You have

• A PhD in life sciences or engineering, molecular biology, biotechnology, bioengineering, chemistry, genomics or a related discipline; or a University Degree with relevant professional experience
• A method development mindset and genuine interest in collaborating and training other scientists to adopt complex workflows
• Experience developing or applying advanced molecular biology, genomics or imaging technologies
• Excellent organizational and communication skills
• Ability to work independently and collaboratively
• Fluency in spoken and written English
• Ideally, strong experimental skills in molecular biology and microscopy
• Ideally, experience working with tissues or complex biological samples

You might also have

• Experience with spatial transcriptomics or spatial omics
• In situ hybridization methods (FISH, in situ sequencing, padlock probes, MERFISH, seqFISH)
• Immunofluorescence, multiplexed immunostaining or DNA barcoding methods
• Advanced fluorescence microscopy and image analysis
• Automation or liquid handling
• Python or R
• Next-generation sequencing technologies

Why join us at the GenTechDev Open Lab

You will help establish next-generation open spatial multiomics technologies used across EMBL and the wider Heidelberg research community. Working alongside internationally recognised experts, you will contribute to scientific innovation, technology transfer, platform development and community building within the MULTI-SPACE initiative.

Contract length: until 31.12.2027 starting as soon as possible, with the possibility of extension contingent upon the availability of grant funding

Salary: Grade 5 or 6 depending on experience (salary starting from EUR 4.147,92 after tax, and before 12.99% EMBL Social Security deductions, plus other paid benefits)

Why join us

EMBL is curiosity-driven, community-oriented and international. As an inclusive, equal opportunity employer, we believe that diversity enables us to collaborate more effectively and be innovative in our approaches. We are, therefore, committed to creating an inclusive and flexible culture - one where everyone can realise their full potential and make a positive contribution to our organisation.

We encourage applications from individuals who can complement our existing team - we believe that success is built on having teams whose backgrounds and personal experiences reflect the diversity of the populations that our science serves. We actively encourage applications from all genders and cultures, ethnic groups and all demographics to help us avoid perpetuating biases and oversights at this transformational point in our people strategy.

Enjoy lots of benefits:

Financial incentives: Salary free of income tax, Monthly family, child and non-resident allowances, an