Principal Scientist / Senior Principal Scientist

Boehringer Ingelheim Pharma GmbH & Co. KG; Biberach an der Riß; Vor Ort; EUR 110.000 - 150.000; Vollzeit

Benefits dieser Stelle

Benefits package

Salary transparency during recruitment

Zusammenfassung

Boehringer Ingelheim Pharma GmbH & Co. KG is seeking a Senior Principal Scientist to advance genotoxicity strategies.

You will coordinate in silico mutagenicity assessments, advise on impurities, and contribute to regulatory submissions, working with global teams in a fast-paced biopharma environment. The role requires strong expertise in mutagenicity, literature research, and collaboration with both German and international stakeholders.

Qualifikationen

• PhD or Master with relevant experience in genetic toxicology or related field.
• Solid knowledge of mutagenicity, structural reactivity and genetic toxicology.
• Expertise in in silico mutagenicity prediction with related software tools.
• Experience in literature research and use of scientific databases.
• Knowledge of pharmaceutical development and genetic toxicology in drug development.
• Ability to coordinate stakeholders and communicate complex findings in German and English.

Aufgaben

• Coordinate, evaluate, and conduct in silico assessments predicting mutagenicity per ICH M7.
• Develop and support derisking strategies for mutagenic impurities across project stages.
• Prepare scientific reports and contribute to regulatory submission documents.
• Advise R&D teams on mutagenic impurities, metabolites, and exposure limits.
• Represent results in international project teams and support risk-based decisions.
• Independently respond to health authority inquiries on ICH M7 topics and align with global requirements.
• Lead the global genotoxicity strategy and manage time-critical regulatory issues.
• Contribute to scientific committees, drive best practices, and foster scientific exchange.

Kenntnisse

In silico mutagenicity prediction

Mutagenicity knowledge

Regulatory science

Stakeholder coordination

German & English communication

Ausbildung

PhD in Chemistry/Biology/Biochemistry or related field

Master in Biology or Computer Science

Tools

In silico tools

Jobbeschreibung

Boehringer Ingelheim is a biopharmaceutical company active in both human and animal health. As one of the industry's top investors in research and development, the company focuses on developing innovative therapies that can improve and extend lives in areas of high unmet medical need. Independent since its foundation in 1885, Boehringer takes a long-term perspective, embedding sustainability along the entire value chain. Our approximately 54,500 employees serve over 130 markets to build a healthier and more sustainable tomorrow. Learnmore atwww.boehringer-ingelheim.com

Tasks & responsibilities

• Your primary responsibilities will include coordinating, evaluating, and conducting in silico assessments to predict mutagenicity in accordance with ICH M7, including the scientific evaluation of related literature searches.
• In close collaboration with i internal and external stakeholders, you will develop and support derisking strategies for mutagenic impurities and metabolites across different stages of project development.
• Furthermore, you will prepare scientific reports, including expert judgment on the relevance of findings, and contribute to regulatory submission documents.
• As a subject matter expert, you will advise Research & Development teams on mutagenic impurities, mutagenic metabolites, and acceptable exposure limits for mutagenic carcinogens.
• In addition, you will represent scientific results and recommendations in international project teams, discuss their implications, and support informed risk-based decision-making.
• You will also independently manage and respond to health authority inquiries related to ICH M7 topics, coordinate global project requirements, and ensure compliance with regulatory expectations and internal procedures.

Additional tasks for the Senior Principal Scientist-Role

• With regard to the global genotoxicity strategy, you will take a leading role in its implementation and further development to ensure the application of avoidance principles and scientifically sound risk assessments.
• Moreover, you will lead complex and time-critical issues with significant regulatory impact and provide recommendations to international stakeholders.
• Additionally, you will contribute to scientific committees and expert forums, foster scientific exchange, and drive the advancement of scientific standards and best practices.

Requirements

• PhD in Chemistry, Biology, Biochemistry Eor comparable scientific degree with relevant professional experience, or Master's degree in Biology or Computer Science
• Solid knowledge of mutagenicity, structural reactivity, and genetic toxicology
• Expertise in in silico mutagenicity prediction, including relevant software tools, derisking strategies, and associated genetic toxicology assays
• Experience in literature research and the use of scientific databases
• Knowledge of pharmaceutical development and the application of genetic toxicology principles in a drug development environment
• Ability to coordinate multiple stakeholders, work effectively under pressure, and communicate complex scientific findings in German and English

Additional requirements for the Senior Principal Scientist-Role

• Extensive experience in applying and interpreting in silico mutagenicity assessments within pharmaceutical development
• Demonstrated capability to lead complex scientific topics and coordinate cross-functional global stakeholders
• Experience in representing scientific positions in interactions with health authorities, scientific committees, or expert forums

As part of our commitment to transparency and fairness, salary information will be shared during the recruitment process. We also offer a comprehensive benefits and wellbeing package.

Applications from persons with severe disabilities are warmly welcomed. In cases of equal qualifications, such applicants will be given preferential consideration in the selection process.

With us, you can develop your own path in a company with a culture that knows our differences are our strengths - and break new ground in the drive to make millions of lives better.

Here, your development is our priority. Supporting you to build a career as part of a workplace that is independent, authentic and bold, while tackling challenging work in a respectful and friendly environment where everyone is valued and welcomed.

Alongside, you have access to programs and groups that ensure your health and wellbeing are looked after - as we make major investments to drive global accessibility to healthcare. By being part of a team that is constantly innovating, you'll be helping to transform lives for generations.