PhD Position – Quantitative Modelling of Tissue Growth

Helmholtz Association of German Research Centers; Jülich; Vor Ort; EUR 52.000 - 66.000; Vollzeit

Benefits dieser Stelle

Team & Environment

Research & Infrastructure

Networking & Exchange

Supervision & Support

Flexible working hours

Annual Leave

Doctoral training (JuDocS)

Health & wellbeing

Zusammenfassung

Helmholtz Association of German Research Centers sucht eine/n PhD-Student/in zur quantitativen Modellierung des Gewebewachstums. Sie arbeiten an einem hochleistungsfähigen Simulationsrahmen und analysieren Experimente in Zusammenarbeit mit Kooperationspartnern.

Im Fokus stehen mechanische Feedback-Regelungen, Gewebemodellierung in 3D und Analytik. Voraussetzungen sind ein Master/Diplom in relevanten Fächern und sehr gute Englischkenntnisse; Deutsch ist von Vorteil.

Qualifikationen

• Interdisziplinäres Forschungsprojekt im Grenzbereich Physik/Biologie.
• Master/Diplom in relevanter Fachrichtung.
• Sehr gute Englischkenntnisse; Deutsch von Vorteil.

Aufgaben

• Weiterentwicklung eines HPC-fähigen Simulationsrahmens.
• Untersuchen, wie Konkurrenz zwischen Zelltypen entsteht.
• Entwicklung analytischer Modelle für beobachtete Phänomene.
• Datenanalyse von Experimente mit Kooperationspartnern.
• Ggf. Besuch von Kooperationen in Harvard Medical.

Kenntnisse

Interdisziplinäre Motivation

Selbstständigkeit

Englischkenntnisse

Deutschkenntnisse wünschenswert

Python

C++

Ausbildung

Master oder Diplom in Physik/Biologie/ Biochemie/ Informatik oder vergleichbar

Tools

Python

C++

Jobbeschreibung

PhD Position – Quantitative Modelling of Tissue Growth

Are you eager to pursue a doctoral project that bridges scientific disciplines? Are you excited by complex challenges that demand interdisciplinary solutions? Are you fascinated by mechanics of growing tissues?

In a collaboration with Harvard Medical School, we recently discovered how mechanical feedback on growth of cells is regulated by the membrane potential. This work has only just begun.

At the Institute for Advanced Simulation – Theoretical Physics of Living Matter (IAS-2), we want to extend this model to the third dimension and explore how mutations could effect growth, and quantitatively describe experimental observations as well as study related effects like cell competition or deformations.

Your Job

• Further development of an advanced simulation framework suitable for high performance computing


• Explore how competition between different celltypes develops


• Develop simplified analytic models for observed phenomena


• Analyse data from experiments from collaborators


• Potentially visit collaborators at Harvard Medical

Your Profile

• Strong motivation for an interdisciplinary project that combines physics and biology together with simulation and data science


• A master’s degree or diploma in physics, biology, biochemistry, informatics or other relevant discipline


• Very good command of written and spoken English with extensive vocabulary is required (at least B2 level according to the CEFR), ideally supported by a certificate confirming the language level


• Knowledge of the German language is not mandatory but a bonus


• High degree of independence and commitment


• Good knowledge of python and C++


• Experience in Simulation sciences are advantageous but not mandatory


• Experience in modelling of tissue growth is advantageous


• Participation and good grades in courses in Theoretical Biophysics, computational methods, python, object oriented programming, c++, Open MP, fluid dynamics, cell biology, will be taken into account

Our Benefits for You

• Team & Environment: You will work in a motivated team with an international and interdisciplinary focus – at one of the largest research institutions in Europe


• Research & Infrastructure: You will have access to excellent scientific and technical facilities for your work


• Networking & Exchange: You will participate in (international) conferences and project meetings and actively build your scientific network


• Supervision & Support: We will accompany your doctoral studies with continuous, expert guidance from your academic supervisor


• Work-life balance: We offer flexible working hours to help you balance your professional and personal life. You also have the option of flexible working (in terms of location), which is generally possible after consultation and in line with upcoming tasks and (on-site) appointments


• Annual Leave: You get 30 days of annual leave


• Knowledge & Development: Your professional development is important to us – we support you specifically and individually e.g., through training and networking opportunities specifically for doctoral candidates (JuDocS)


• Health & well-being: Your health is important to us. You can look forward to a comprehensive company health management programme with a wide range of options, including a beach volleyball court, running groups, yoga classes and much more. In addition, our company medical service and an experienced social counselling team are available to assist you on site


• Fair remuneration: Depending on your qualifications and assigned responsibilities, you will be classified according to pay group 13 (75%) of the TVöD-Bund. In addition to the basic salary, there is an additional year-end bonus under the collective pay agreement amounting to 75% of a monthly salary, as well as capital-forming benefits. All information about the TVöD-Bund collective agreement can be found on the BMI website (pay scale table on page 66 ff. of the PDF download)


• Fixed-term: The position is limited to 3 years


• Support for international employees: Our International Advisory Service makes it easier for international employees to get started

Diversity and Inclusion

We welcome applications from people with diverse backgrounds, e.g. in terms of age, gender, disability, sexual orientation / identity, and social, ethnic and religious origin. A diverse and inclusive working environment with equal opportunities in which everyone can realize their potential is important to us.

Place of Employment: Jülich Start Date: To the next possible date Salary: Pay group 13 (75%) TVöD-Bund