PhD Position (mfd) Project P04 "Protective & pathogenic antibody responses at barrier organ

UKSH Universitätsklinikum Schleswig-Holstein; Kiel; Vor Ort; EUR 48.000; Teilzeit

Zusammenfassung

A leading research institution in Germany is seeking a PhD Candidate for a project focusing on the mechanisms of IgE and IgG antibodies in food allergies. The successful candidate will conduct research using advanced techniques, participate in a structured qualification program, and collaborate closely with experts from Kiel University and the University of Lübeck. This position offers a part-time opportunity with a competitive salary and excellent research environment.

Leistungen

Participation in structured qualification programme

Access to state-of-the-art technologies

Opportunities for scientific networking

Qualifikationen

• Masters degree in life sciences or related discipline required.
• Experience in mouse models, flow cytometry, and cellular biology is beneficial.
• Motivation to use bioinformatics for data analysis preferred.

Aufgaben

• Conduct doctoral research on IgE and IgG clones in food allergy.
• Contrast IgE glycosylation in AD patients and controls.
• Participate in scientific programs and present research findings.

Kenntnisse

Experience with mouse models

Flow cytometry

Molecular and cellular biology techniques

Knowledge of German

Bioinformatics approaches for data analysis

Experience with R or comparable software

Ausbildung

Masters degree or equivalent in life sciences

Jobbeschreibung

The DFG-funded Research Training Group (RTG) 3095 Protective and pathogenic antibody responses at barrier organs is a collaborative doctoral programme jointly organized by theUniversity of LübeckandKiel University two modern and research-intensive universities with strong profiles in medicine molecular biology and life sciences. Their study programmes have consistently achievedtop rankings in the CHE Ranking the most comprehensive evaluation of study programmes at German universities.

Immunological barrier organs such as theskin intestine and lungsare continuously exposed to commensal microorganisms pathogens and environmental allergens. As a result infections as well as allergic and autoinflammatory disorders at these mucosal interfaces are frequent and represent asignificant burden to public health. Antibody-mediated immune responses play acentral rolein maintaining homeostasis at these sites : they contribute to thecontrol of pathogen invasion theregulation of gut microbiota and theinitiation and modulation of allergic reactions while also exerting regulatory functions that candownregulate inflammation.

The overarching goal of RTG 3095 is to elucidate themechanisms by which B cell responses are initiated maintained and contribute to either immunoprotection or immunopathogenesisat these immunological barrier sites. To achieve this the programme employsstate-of-the-art experimental approaches includingsingle-cell sequencingspatial transcriptomics and advanced molecular and immunological techniques. Doctoral researchers will benefit from astructured 4-year training programmethat integrates cutting-edge research with comprehensive training opportunities.

Start in our team

Within this framework the subproject P04 Generation of IgE and IgG antibodies with differential allergenic / anti-allergenic potentialled byProf. Matthias Peipp (Kiel University) and Prof. Ralf Ludwig (University of Lübeck)is seeking aPhD Candidate to start on April 1 2026 . The position is initially limited until March 31 2030 . The position is localized at Kiel University (laboratory Prof. Peipp).

What we offer :

• The salary will be based on the German E13 TV-L scale (65%) if terms and conditions under collective bargaining law are fulfilled
• Part-time employment currently 25 hours / week
• Participation in the structured qualification programme of RTG 3095 including workshops courses and summer schools in state-of-the-art immunology related research
• A highly stimulating research environment with access to state-of-the-art technologiessuch as single-cell sequencing and spatial transcriptomics
• Excellent opportunities for scientific networking and qualification in cutting-edge immunological research

Your tasks

• Conducting a doctoral research project within P04 focusing on the mechanisms by which individual IgE and IgG clones drive or protect from food allergy development.
• Contrast IgE glycosylation in atopic dermatitits (AD) patients and non-AD controls. Generation of recombinant complete allergen-specific antibodies with murine IgE or IgG1 Fc with different affinities and effector properties and to study the pathogenic or protective roles of these antibodies in a murine mouse model of AD.
• Active participation in the scientific programme of the RTGs graduate training activities
• Presentation and discussion of research findings within the research consortium

Your profile

• A Masters degree (or equivalent) in the life sciences or a related discipline fulfilling the formal requirements for enrolment as a doctoral candidate at the University of Lübeck
• Experience with mouse models flow cytometry and molecular and cellular biology techniques as well as knowledge of German are advantageous
• Motivation to apply bioinformatics approaches for the analysis of high-throughput datasets (e.g. scRNA-seq); experience with R or comparable statistical software is desirable
• Strong motivation to contribute your own ideas to a dynamic interactive research team
• Independent structured and collaborative working style

Application

Please submit your application until 31 December 2025 indicating the reference number 27557.

Please include the following documents with your application :

• Amotivation letter(maximum one page) which also indicates if you are also interested in other projects within the RTG 3095 (a maximum of 3 projects)
• Acurriculum vitae(including a list of publications if applicable)
• Certificatesand transcripts of your previous university degrees (BSc / MSc including transcripts of records)
• at leastone letter of recommendation
• Names andemail addresses of twopotential references

Selection process

Application to this subproject of RTG 3095 is generally considered to be an application also to the other subprojects of RTG 3095. Separate application to another subproject is not required but please indicate in your motivation letter your favored RTG3095 subprojects (see above motivation letter).

Among the written applications the most suitable candidates will be invited to a one-day symposium which will take place in January 2026 in Lübeck Germany.

For further information please contact : Prof. Matthias Peipp () Kiel University