PhD Candidate in Translational Pancreatitis and Thromboinflammation Research; part time 65 (m/w/d)

Klinikum der Universität München; München; On-site; EUR 51,000 - 61,000; Full time

Job summary

Das Klinikum der Universität München sucht promovierende Forscherinnen und Forscher für ein interdisziplinäres SFB-Projekt zur thromboinflammatorischen Mechanismen der Pankreatitisentwicklung. Sie arbeiten an zellulären Modellen, Patientproben und präklinischen Systemen und nutzen moderne molekulare und zellbiologische Techniken.

Sie planen Experimente, analysieren Daten und berichten auf internen Meetings sowie nationalen/internationalen Konferenzen.

Qualifications

• Abgeschlossenes Hochschulstudium, idealerweise Master in Biologie, Biochemie, Molekulare Medizin oder verwandtem Life-Science-Fachgebiet.
• Starkes Interesse an translationaler Forschung, Entzündung, Pankreatitis, Gefäßbiologie oder Immunologie.
• Praktische Erfahrung in Molekular- und Zellbiologie (z. B. Zellkultur, Durchflusszytometrie, Mikroskopie, Immunoblot, qPCR).
• Vorteilhaft, aber nicht zwingend: Erfahrung mit Primärzellen, Patientenproben, Tiermodellen, Proteomik oder Nanopartikel/Drug-Delivery-Systemen.
• Motivation zum Erlernen neuer Technologien und quantitative Analysen.

Responsibilities

• Arbeiten an einem SFB-Projekt zur Thromboinflammation bei Pankreatitis.
• Untersuchung zellulärer und molekularer Mechanismen, vaskuläre Biologie und Immunologie.
• Planung und Durchführung von Experimenten mit zellbasierten Systemen, Patientenproben und Modellen.
• Anwendung moderner Methoden wie Zellkultur, Durchflusszytometrie, Immunfluoreszenz, RNA- und Protein-Analytik.
• Dokumentation, Datenanalyse und Präsentation von Ergebnissen intern und auf Konferenzen.

Skills

Interesse Translationalforschung

Englisch fließend

Teamfähigkeit

Kommunikationsstärke

Education

Master in Biologie/ Biochemie/ Molekulare Medizin

Job description

Scope of duties

• Work on the Collaborative Research Centre project (SFB) “Thromboinflammatory mechanisms of pancreatitis progression and associated splanchnic and portal vein thrombosis”
• Investigate cellular and molecular mechanisms that link pancreatic inflammation, coagulation and thrombotic complications
• Study the role of platelet–neutrophil interactions and sphingolipid metabolism in acute and acute-on-chronic pancreatitis
• Plan and perform experimental studies using cellular systems, patient-derived biosamples and established preclinical models of pancreatitis
• Apply modern molecular, biochemical and cell biological methods, including cell culture, flow cytometry, immunofluorescence microscopy, RNA and protein analysis and functional cellular assays
• Contribute to the characterization of inflammatory, thrombotic and metabolic pathways using proteomic, lipidomic or transcriptomic approaches
• Participate in the development and validation of targeted therapeutic strategies, including nanoparticle- and aptamer-based delivery approaches
• Quantitatively analyze, interpret and document experimental and clinical research data
• Collaborate closely with scientists, clinicians and technology platforms within the interdisciplinary Collaborative Research Centre
• Present research findings at internal meetings and national and international scientific conferences and contribute to scientific publications

Our requirements

• A successfully completed university degree, preferably a Master’s degree or equivalent, in biology, biochemistry, molecular medicine, biotechnology, pharmacy or a related life-science discipline
• Strong interest in translational research, inflammation, pancreatitis, vascular biology or immunology
• Practical experience in molecular and cell biology, for example mammalian cell culture, flow cytometry, microscopy, immunoblotting, quantitative PCR or functional cellular assays
• Previous experience with primary cells, patient samples, animal models, proteomics, lipidomics, nanoparticles or drug-delivery systems is an advantage, but not mandatory
• Motivation to learn new experimental technologies and quantitative analysis methods
• A careful, structured and reliable approach to experimental work
• Scientific curiosity, high motivation and the ability to work both independently and as part of a team
• Strong communication skills and enthusiasm for working in an interdisciplinary and international research environment
• Very good written and spoken English
• German language skills are not required

Our offer

• An innovative PhD project within an interdisciplinary Collaborative Research Centre at LMU University Hospital
• A translational research environment combining experimental pancreatitis research, vascular biology, immunology and clinical medicine
• The opportunity to work with patient-derived biosamples, established disease models and modern molecular and imaging technologies
• State-of-the-art laboratories and access to advanced flow cytometry, microscopy, proteomics, lipidomics and data-analysis platforms
• Close collaboration with basic scientists, clinician scientists, bioinformaticians and experts in vascular and inflammatory biology
• Integration into a highly collaborative national research network with opportunities for scientific exchange across several disciplines
• Structured scientific supervision and support for professional and personal development
• Opportunities to participate in scientific workshops, training programmes and national and international conferences
• A supportive and inspiring working environment that encourages scientific independence and the development of new ideas
• Employment according to the German public-sector collective agreement, including annual leave and additional benefits in accordance with the applicable regulations
• The position is initially limited to three years. The precise wording regarding a possible extension should be adapted to the SFB funding conditions
• The position is based at LMU University Hospital, Campus Großhadern, in Munich
• Remuneration is based on the Collective Agreement for the Public Sector of the Länder (TV-L) including all allowances customary in the public sector.