NBE DMPK Lead (all genders), limited for 2 years

Merck KGaA; Darmstadt; On-site; EUR 70,000 - 100,000; Full time

Job summary

IT-Systemhaus der Bundesagentur für Arbeit is seeking an NBE DMPK Lead to oversee the pharmacokinetics strategy for innovative biotherapeutics. This role requires a doctoral degree in Pharmacokinetics or a related field and substantial experience in the pharmaceutical industry. You will work closely with cross-functional teams to ensure successful drug development and submissions.

The position is a 2-year contract based in Darmstadt, Hessen, focusing on integrating modeling tools and guiding project direction.

Qualifications

• PhD with industry experience in pharmacokinetics or related field.
• Substantial experience in pharmaceutical or biotechnology industry.
• Knowledge of drug discovery and regulatory requirements.

Responsibilities

• Define DMPK strategy for drug molecules.
• Integrate models and generate insights for human dose predictions.
• Guide cross-functional project teams.

Skills

Fluent in English

Hands-on experience with quantitative modeling

Communication of scientific concepts

Organizational skills

Education

PhD in relevant field

Degree in Pharmacokinetics or related field

Tools

Modeling and Simulation tools

Python

R

Job description

Stellendetails zu: NBE DMPK Lead (all genders), limited for 2 years

NBE DMPK Lead (all genders), limited for 2 years

NBE DMPK Lead (all genders), limited for 2 years

Beginn

• Biologe/Biologin

Work Your Magic with us!

Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.

Your Role:

At the intersection of scientific innovation and patient impact, this role places you at the heart of next-generation biotherapeutic development. As the NBE DMPK Lead, you will serve as the authoritative scientific expert for drug metabolism and pharmacokinetics across a portfolio of novel biological entities — including ADCs, AOCs, and multispecific biologics. You will define the DMPK strategy for each molecule, integrating PK, immunogenicity, and bioanalytical approaches to de-risk clinical development and drive health authority submissions. Applying Modeling and Simulation, you will generate data-driven insights to inform molecular design and translate preclinical findings into human dose predictions. Embedded in cross-functional project teams, you will guide peers and senior stakeholders — shaping the scientific direction of your projects.

This position is limited for two years.

Who You Are:

• You hold a degree or equivalent qualification in Pharmacokinetics, Pharmaceutical or Biotechnological Sciences, Biomedical or Chemical Engineering, Applied Mathematics, or a related biological or chemical discipline; a doctoral degree with relevant industry experience is typical for this level.
• You bring substantial professional experience in the pharmaceutical or biotechnology industry, with deep expertise in PK/PD concepts across drug discovery and development — including translational sciences and regulatory requirements for biotherapeutics such as ADCs, AOCs, and multispecific biologics.
• You have hands-on experience with quantitative modeling approaches, including M&S tools, population PK software, QSP platforms, or programming environments such as Python or R; experience with AI/ML applications in drug development is a strong advantage.
• You possess a solid understanding of adjacent disciplines — including pharmacology, toxicology, nonclinical safety, drug design, and bioanalytics — and can integrate insights across these areas to guide biotherapeutic engineering and optimization.
• You communicate complex scientific concepts clearly and confidently to diverse audiences, including cross-functional project teams and senior stakeholders, and are comfortable influencing decisions without direct authority.
• You are fluent in written and spoken English; proficiency in German or Italian is an advantage.
• You bring strong organizational skills, intercultural awareness, and the ability to manage multiple project commitments with a high degree of autonomy.

What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!

Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!