Master Thesis: Development of Synthetic Lymph Nodes to study Leukemia Therapy Resistance

INM GmbH; Saarbrücken; Vor Ort; EUR 40.000 - 60.000; Vollzeit

Zusammenfassung

A research institute in Saarbrücken is offering a master's thesis project focusing on the development of synthetic lymph nodes to study leukemia therapy resistance. Candidates with backgrounds in cell biology, biomaterials, or biophysics are encouraged to apply. The project involves advanced techniques such as 3D cancer cell culture, immuno-staining, and advanced microscopy. Applications are due by December 15th, 2025.

Leistungen

Flexible work hours

Family-friendly policy

Flextime and mobile working opportunities

Qualifikationen

• Background in cell biology, biomaterials or biophysics (or related fields) required.
• Experience with advanced microscopy and biochemical assays is a plus.

Aufgaben

• Develop synthetic lymph nodes to study leukemia therapy resistance.
• Utilize various techniques including 3D cancer cell culture and immuno-staining.

Kenntnisse

Cell biology

Biomaterials

Biophysics

3D cancer cell culture

Immuno-staining

Flow cytometry analysis

Advanced microscopy

Biochemical assays

Radiometric assays

Ausbildung

Master's degree in relevant field

Jobbeschreibung

INM’s research group Immuno-Materials combines expertise from synthetic biology, biomaterials and immunology to develop new approaches for studying and regulating immune reactions.

Are you a master student (f/m/d) with a background in cell biology, biomaterials or biophysics (or related fields) and looking for a thesis project? This might be something for you!

Master Thesis

Development of synthetic lymph nodes to study leukemia therapy resistance

Starting on February 1st, 2026 (with flexibility).

We have pioneered the development of synthetic lymph nodes formed from artificial cells that can mimic the microenvironment of leukemia cells. This approach can be applied to form artificial tumor microenvironments with defined properties and systematically study therapy resistance mechanisms. We are able to induce specific molecular and biophysical changes in the synthetic lymph nodes that mimic the signaling induced by the extracellular matrix and other immune cells in the lymph nodes. The master thesis should study the effects of the extracellular matrix in conjunction with intercellular signaling on therapy resistance of chronic lymphocytic leukemia.

Techniques applied include:

• 3D cancer cell culture
• Immuno-staining with flow cytometry analysis
• Advanced microscopy (light-sheet microscopy, confocal fluorescence microscopy)
• Biochemical and radiometric assays

Interested? We are looking forward to receiving your application (CV, B.Sc. certificate or transcripts of record, motivation letter) by December 15th, 2025. Please send it via our online applications system (single pdf file < 5 MB).

The INM practices an open and appreciative corporate culture in which the existing diversity is promoted and lived. The institute is an equal opportunity employer with a certified family-friendly policy, and it provides offers for a better work-life balance, flextime, and mobile working. We promote professional opportunities for women and strongly encourage them to apply. Severely disabled applicants with equal qualifications and aptitude will be given preferential consideration.