Student Internship - Process Development for Oligonucleotides

F. Hoffmann-La Roche AG; Basel; Vor Ort; CHF 16.000 - 22.000; Vollzeit

Benefits dieser Stelle

Mentorship

Hands-on training

Competitive internship compensation

Zusammenfassung

Roche is offering a 12-month internship in Global Technical Development (PTDC) focused on upstream oligonucleotide manufacturing process development. You will develop cost-efficient and robust processes in a lab setting, document results and collaborate with cross-functional teams across the organization.

The role provides mentorship, hands-on training, and exposure to cutting-edge oligonucleotide process development and manufacturing methodologies within a global biopharmaceutical environment.

Qualifikationen

• Enrollment at a university as a Master student, or completed Master studies no longer than 12 months, in Chemistry/Biochemistry/Chemical Engineering or related field.
• Good understanding of organic chemistry and process chemistry.
• Hands-on experience in the laboratory.
• Initiative and teamwork with responsibility and flexibility.
• Experience with oligonucleotide chemistry, HPLC analysis and/or downstream techniques is an advantage.

Aufgaben

• Support process development of oligonucleotide manufacturing focusing on upstream process to develop cost-efficient, novel and robust processes.
• Develop oligonucleotide manufacturing processes in a lab setting, establishing suitable synthesis conditions, conducting analytical tests to evaluate quality and yield, and interpreting data.
• Develop end-to-end control strategies for the quality of the oligonucleotide manufacturing process, considering impurity origin, process robustness, and control points.
• Collaborate with cross-functional teams to ensure successful implementation of processes.
• Participate in team meetings and contribute to problem-solving discussions and presenting results.
• Document experimental procedures, results, and observations in a clear and organized manner.

Kenntnisse

Master student enrollment

Master studies completed within 12m

Chemistry / Biochemistry / Chemical En

Organic chemistry knowledge

Process chemistry knowledge

Laboratory hands-on experience

Initiative and teamwork

Responsibility and flexibility

Oligonucleotide chemistry (advantage)

HPLC analysis (advantage)

Ausbildung

Master degree in Chemistry / Biochemistry / Chemical Engineering

Tools

HPLC analysis

Ultrafiltration

Preparative HPLC

Jobbeschreibung

About Roche

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally.

This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

Position

At Roche, we believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives. We are courageous in both decision and action, we believe that good business means a better world. Behind every presentation of each product sold by Roche is the involvement of Pharma Global Technical Operations (PT). Starting with Phase I of the development process and continuing through to product maturity, PT makes medicines at sites around the world and includes more than 10 000 employees worldwide.

Opportunity

In \"Global Technical Development\" (PTD), we actively collaborate and develop creative technical solutions to efficiently transform scientific ideas into products. Our mission is to reliably deliver the pipeline and supply quality products to patients. The group excels in its work through innovation, teamwork, dedication, and mutual respect and contributes every single day, continuously improving what it does. Synthetic Molecules Technical Development (PTDC) is responsible for technical development of the synthetic pipeline molecules and for the manufacture of Drug Substance and Drug Product for clinical studies. PTDC brings a broad range of experience across Drug Substance and Drug Product and analytical sciences, and collaborates closely with key partners in Research and Early Development (pRED / gRED) and with our synthetic molecules commercial manufacturing network.

To support process development for therapeutic oligonucleotides, we offer the following internship position for 12 months with the opportunity to gain impactful experience in the biopharmaceutical industry.

Responsibilities

You will be responsible for the following main tasks: Supporting process development of oligonucleotide manufacturing focusing on the upstream process to develop cost-efficient, novel and robust processes.

Develop oligonucleotide manufacturing processes in a lab setting, taking responsibility for establishing suitable synthesis conditions, conducting analytical tests to evaluate quality and yield, and interpreting data.

Develop end-to-end control strategies for the quality of the oligonucleotide manufacturing process, taking into account the origin and fate of impurities, process robustness, and control points.

Collaborate with cross-functional teams to ensure the successful implementation of processes.

Participate in team meetings and contribute to problem-solving discussions and presenting results.

Document experimental procedures, results, and observations in a clear and organized manner.

Internship Details

With this role, we offer a collaborative work environment and competitive internship compensation. You will receive dedicated mentorship and hands‑on training, giving you direct exposure to cutting‑edge technologies and methodologies in oligonucleotide process development and manufacturing.

Key qualifications and skills

Enrollment at a university as a Master student, or completed Master studies no longer than 12 months, in the field of Chemistry / Biochemistry, Chemical Engineering, or related field. Good understanding of organic chemistry and process chemistry. Hands‑on experience in the laboratory. Working style driven by initiative, team focus, responsibility and flexibility. Ideally, experience with oligonucleotide chemistry, HPLC analysis, and/or downstream techniques such as ultrafiltration and preparative HPLC is an advantage. Non‑EU/EFTA citizens must include confirmation from the university with their application documents that a compulsory internship is part of the training.

Who We Are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life‑changing healthcare solutions that make a global impact. Let’s build a healthier future, together.

Roche is an Equal Opportunity Employer. We believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives. We are courageous in both decision and action. And we believe that good business means a better world. That is why we come to work each day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow. We are proud of who we are, what we do, and how we do it. We are many, working as one across functions, across companies, and across the world. We are Roche.