Internship in Oligonucleotide Synthesis (as of September for 12 months - 3 openings in Basel)

Roche; Basel; On-site; CHF 17,000 - 23,000; Full time

Job summary

Roche in Basel invites you to join the Preclinical Chemistry, Manufacturing, and Controls (pCMC) team within pRED for an internship. You will explore either oligonucleotide synthesis and purification or advanced LC-MS analytics, gaining hands-on laboratory experience and collaboration across a dynamic, science-driven environment.

The position emphasizes curiosity, responsibility, and teamwork, with opportunities to contribute to innovative drug development while developing critical lab skills

Qualifications

• BSc or MSc student or recent graduate in Chemistry or Biochemistry, within 12 months of start date.
• Hands-on laboratory experience required.
• Experience with oligonucleotide chemistry or LC-MS analytics is desirable.
• Excellent written and verbal communication in English.
• Strong organizational skills and willingness to learn.

Responsibilities

• Option 1: contribute to oligonucleotide synthesis, purification, and analysis using state-of-the-art chromatography; scale up to multi-gram materials.
• Option 2: perform state-of-the-art LC-MS analysis of complex oligonucleotides; develop analytical methods for synthesis and production; conduct stability and hold-time studies.

Skills

Oligonucleotide chemistry

LC-MS analytics

Synthesis purification

English communication

Education

BSc or MSc in Chemistry or Biochemistry

Tools

LC-MS instruments

Solid phase synthesis equipment

Job description

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Position

We advance science so that we all have more time with the people we love.In Roche´s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed. This position is located in Preclinical Chemistry, Manufacturing, and Controls (pCMC), a department within the small molecule research organization in pRED Therapeutic Modalities, where we pave, in a diverse, ambitious and innovative environment, the path to bring drug candidates from early research into development.

The Opportunity

As an Intern in our team your main tasks will include:

• Option 1 - Oligo synthesisDiscovery of new techniques for the synthesis of complex oligonucleotidesPurification and analysis of reactions involving oligonucleotides with state of the art chromatographic techniques.Scale up your findings into processes for the preparation of multi-gram quantities of desired target materials.
• Option 2 - Oligo Analytical ChemistryState-of-the-art analysis of complex synthetic oligonucleotides by LC-MS.Development and implementation of innovative analytical methods to support synthesis, development and production.Conducting critical in-solution stability and hold-time studies.

Who you are

• An enthusiastic, motivated and scientifically interested person who enjoys teamwork and has a strong willingness to learn new techniques.
• A BSc or MSc student, or a recent graduate (within the last 12 months prior to the start date), in Chemistry or Biochemistry. Prior hands-on laboratory experience is required.
• Prior experience with oligonucleotide chemistry (solid phase synthesis, conjugation, purification and analysis; Option 1) or LC-MS analytics (Option 2) is desirable.
• Excellent organizational skills and proactive knowledge sharing.
• Excellent written and verbal communication skills in English.

Additional Information

Please note, due to regulations, non-EU/EFTA citizens must provide a certificate from the university stating that an internship is mandatory as part of the application documents, and must be continuously enrolled in their university for the whole duration of this internship.this internship is not suitable for a thesis, nor for PhD students or post-graduates.

If you are eager to contribute and feel you have the dedication to teamwork and innovation that we are seeking, then Roche is the organization for you. Every role at Roche plays a part in making a difference to patients’ lives. If you want to work in a passionate team, make your mark & improve lives, apply now!

Who we are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.Let’s build a healthier future, together.Roche is an Equal Opportunity Employer.