Scientist, Cell Engineering and Phenotypic Screening Models

Roche Holding AG; Basel; Vor Ort; CHF 90.000 - 120.000; Vollzeit

Zusammenfassung

Roche sucht eine/n Wissenschaftler/in für Small Molecule Research Discovery im pRED-Bereich. Sie entwickeln zellbasierte Modelle, integrieren Screening-Workflows und arbeiten eng mit Automatisierung, Datenanalyse und Chemie zusammen.

Sie verfügen über ein PhD in Zellbiologie oder Molekularbiologie, Erfahrung mit CRISPR/Cas, Zelllinien-Generierung und Hochdurchsatz-Screening. Die Stelle ist 100% Laborbasis am Standort Basel und erfordert fließendes Englisch.

Qualifikationen

• PhD in cell biology, molecular biology, or related field.
• Postdoctoral or industry research experience is a plus but not required.
• Hands-on cell culture expertise including iPSC differentiation.
• Extensive genome editing with CRISPR/Cas, stable cell lines, genotyping.
• Cloning, transfection, viral transduction, and vector design.
• Experience with high-content imaging or high-throughput screening is a plus.
• Fluent English communication.

Aufgaben

• Model Innovation: Independently design, engineer, validate, and optimize disease-relevant cellular models at scale to enable phenotypic screening and small molecule drug discovery.
• Advanced Engineering: Apply diverse cell engineering approaches, including CRISPR/Cas technologies, vector design, reporter systems, and stable cell line generation.
• Pipeline Integration: Translate complex cellular models into scalable, reproducible, screening-compatible workflows for high-content imaging and phenotypic screening.
• Cross-Functional Collaboration: Partner across therapeutic areas, automation, data analysis, and chemistry teams to interpret results and support decisions.
• Culture Contribution: Cultivate an inclusive, collaborative, and curious team environment.

Kenntnisse

Cell Culture Expertise

Advanced Genome Editing

Molecular Biology Proficiency

Imaging & Screening

Communication & Mindset

Ausbildung

PhD in cell biology / molecular biology

Tools

CRISPR/Cas

NGS

High-content imaging

Jobbeschreibung

Bei Roche kannst du ganz du selbst sein und wirst für deine einzigartigen Qualitäten geschätzt. Unsere Kultur fördert persönlichen Ausdruck, offenen Dialog und echte Verbindungen. Hier wirst du für das, was du bist, wertgeschätzt, akzeptiert und respektiert. Dies schafft ein Umfeld, in dem du sowohl persönlich als auch beruflich wachsen kannst. Gemeinsam wollen wir Krankheiten vorbeugen, stoppen und heilen und sicherstellen, dass jeder Zugang zur Gesundheitsversorgung hat – heute und in Zukunft. Werde Teil von Roche, wo jede Stimme zählt.

Die Position

In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

Therapeutic Modalities (TMo) organization, accountable for translating disease biology into high-quality drug candidates across small molecules, large molecules, oligonucleotides, and genomic medicines. By integrating deep modality expertise with cross-disciplinary collaboration, TMo drives innovation within and across platforms to enable differentiated, sustainable therapeutic impact.

The Opportunity

Joining Small Molecule Research Discovery within Therapeutic Modalities, you will work within a highly engaged, cross-functional team bridging cell biology, automation, and multiple therapeutic areas. In this role, you drive innovation through strong commitment to lab science by developing the foundational cellular models that power our drug discovery pipeline.

Key responsibilities include:

• Model Innovation: Independently design, engineer, validate, and optimize disease-relevant cellular models at scale to enable phenotypic screening and small molecule drug discovery.

• Advanced Engineering: Apply diverse cell engineering approaches, including CRISPR/Cas technologies, vector design, reporter systems, and stable cell line generation, to build robust assay systems.

• Pipeline Integration: Translate complex cellular models into scalable, reproducible, screening-compatible workflows for high-content imaging and phenotypic screening.

• Cross-Functional Collaboration: Partner actively across therapeutic areas, automation, data analysis, and chemistry teams to interpret results, present data, and support project decisions.

• Culture Contribution: Actively cultivate an inclusive, collaborative, and curious team environment focused on pushing scientific boundaries.

Who You Are

You are a curious, highly motivated scientist who thrives on solving complex biological challenges. You bring a collaborative mindset and are eager to apply your technical expertise to discover life-changing treatments.

To thrive in this role, you bring:

• Education & Experience: A PhD in cell biology, molecular biology, or a closely related scientific discipline. Postdoctoral or industry research experience is a plus but not required.

• Cell Culture Expertise:Strong hands-on experience in advanced cell culture techniques, including iPSC differentiation and larger-scale cell culture.

• Advanced Genome Editing:Extensive practical experience in cell engineering, particularly CRISPR/Cas-based genome editing, stable cell line generation, clonal isolation, genotyping, and validation using Next-Generation Sequencing (NGS).

• Molecular Biology Proficiency: Solid experience with cloning, transfection, viral transduction, nucleofection, as well as plasmid, vector, and genetic element design (promoters, reporters, tags).

• Imaging & Screening:Solid exposure to high-content imaging, assay development, automated cell culture, or high-throughput screening using small molecules or genetic tools. Expertise in high-content data analysis, image processing pipelines, or multiparametric data evaluation is a plus.

• Communication & Mindset: Resourceful, flexible problem-solving skills with a highly collaborative approach and strong communication skills in English.

Please be advised that this position is 100% lab-based.

Wer wir sind

Eine gesündere Zukunft treibt uns zur Innovation an. Mehr als 100.000 Mitarbeiter weltweit arbeiten gemeinsam daran, wissenschaftliche Fortschritte zu erzielen und sicherzustellen, dass jeder Zugang zur Gesundheitsversorgung hat – heute und für zukünftige Generationen. Durch unser Engagement werden über 26 Millionen Menschen mit unseren Medikamenten behandelt und mehr als 30 Milliarden Tests mit unseren Diagnostik-Produkten durchgeführt. Wir ermutigen uns gegenseitig, neue Möglichkeiten zu erkunden, Kreativität zu fördern und hohe Ziele zu setzen, um lebensverändernde Gesundheitslösungen zu liefern.

Gemeinsam können wir eine gesündere Zukunft gestalten.

Roche ist ein Arbeitgeber, der die Chancengleichheit fördert.