Research Scientist: RNAi Formulations

Proclinical; Schweiz; On-site; CHF 40,000 - 44,000; Full time

Job summary

Proclinical is seeking an Associate Research Scientist for RNAi Formulations to perform hands-on formulation development and biophysical characterization for preclinical RNAi and oligonucleotide therapeutics in a fast-paced research setting.

The role requires MS or PhD with relevant experience; proficiency in analytical testing, data analysis, and DOE-based optimization is valued, along with strong communication across disciplines.

Qualifications

• MS or PhD in pharmaceutical sciences, formulation sciences, chemical engineering, biophysics, analytical chemistry, oligonucleotide delivery, or related discipline.
• Hands-on oligonucleotide or antibodies/proteins formulation and characterization experience preferred.
• Experience developing or running analytical methods for solubility, viscosity, osmolality, aggregation, stability for complex formulations.

Responsibilities

• Support development and characterization of preclinical RNAi and oligonucleotide formulations across projects.
• Execute hands-on formulation prep, biophysical characterization, analytical testing, and data analysis.
• Establish and run screening assays for oligonucleotides in early discovery, including solubility and stability assessments.
• Contribute to high-throughput and DOE-based formulation optimization.
• Support long-term storage and stability evaluations for RNAi conjugates.
• Maintain accurate experimental documentation and communicate findings through reports and presentations.
• Collaborate with internal and external partners to support project deliverables.
• Identify gaps and propose practical improvements to workflows.
• Thrive in a multidisciplinary, fast-paced research environment.

Skills

RNAi formulation

DoE optimization

Automation & HTS

Analytical testing & data analysis

Scientific communication

Education

MS or PhD in related field

Job description

Research Scientist: RNAi Formulations - Contract - Lexington, MA

Looking to be the heartbeat of medical research? Join our client as a Research Scientist and assist in turning innovative science into life-changing care!

Proclinical is seeking an Associate Research Scientist for RNAi Formulations to be focused on hands-on RNAi formulation development.

Primary Responsibilities:

This position will also focus on biophysical and analytical characterization as well as support the oligonucleotide delivery activities for injectable therapeutics.

Skills & Requirements:

• MS with approximately 3 years of relevant experience, or PhD with 1-3 years of relevant experience in pharmaceutical sciences, formulation sciences, chemical engineering, biophysics, analytical chemistry, oligonucleotide delivery, or a related discipline.
• Hands-on experience with oligonucleotide or antibodies/proteins formulation and characterization is strongly preferred.
• Experience developing or running analytical methods for solubility, viscosity, osmolality, aggregation, , stability, or other developability assessments for complex oligonucleotide or antibody/protein formulations.
• Familiarity with automation, high-throughput screening, and DoE-based formulation optimization is an advantage.
• Strong experimental planning, documentation, data analysis, and problem-solving skills.
• Excellent verbal and written communication skills, with the ability to work effectively across disciplines and functions.
• Awareness of external trends and advances in RNA delivery, oligonucleotide therapeutics, and clinical translation is a plus.
• A track record of scientific contributions, publications, or conference presentations in relevant areas is a plus.

The Research Scientist's responsibilities will be:

• Support the development and characterization of preclinical RNAi and oligonucleotide formulations across portfolio and platform projects.
• Execute hands‑on formulation preparation, biophysical characterization, analytical testing, and data analysis to support formulation selection and developability assessments.
• Establish and run screening assays for oligonucleotides in early discovery, including formulation performance, solubility, viscosity, osmolality, degradation, , and stability assessments.
• Contribute to high-throughput and design-of-experiments approaches for formulation optimization, where applicable.
• Support long‑term storage and stability evaluations for RNAi conjugates and oligonucleotide formulations.
• Maintain accurate experimental documentation and communicate findings through written summaries, reports, and internal presentations.
• Collaborate with internal stakeholders and external partners to support project deliverables and timelines.
• Identify technical gaps, propose practical solutions, and contribute to continuous improvement of formulation and characterization workflows.
• Thrive in a multidisciplinary, fast‑paced research environment with competing priorities and tight deadlines.

Compensation:

• $35 to $39 per hour.