Postdoctoral Researcher - Experimental Hematology and Functional Genomics 80-100%

Universitätsspital Zürich; Zürich; On-site; CHF 90,000 - 115,000; Full time

Benefits offered by this job

Fully funded position

International environment

Access to state-of-the-art tech

Job summary

The Boettcher Lab at University Hospital Zurich invites applications for a Postdoctoral Researcher to lead a project on hematopoietic stem cell dysfunction, combining molecular biology with preclinical models. You will design experiments, develop disease models, and apply CRISPR-based approaches, contributing to publications and conferences in an international setting.

The position is fully funded for 3–4 years, offering an international research environment and collaboration with the University

Qualifications

• PhD in molecular biology, biomedical sciences, genetics, cancer biology, or a related discipline.
• Strong experimental background in molecular and cellular biology.
• Experience with genome editing, functional genomics, or stem cell biology is highly desirable.

Responsibilities

• Independently design, coordinate, and perform experimental research projects.
• Establish and characterize advanced in vitro and in vivo disease models.
• Develop and apply CRISPR-based genome editing and functional genomics approaches.
• Conduct mechanistic investigations using molecular and cellular techniques.
• Analyze and interpret complex experimental datasets.
• Supervise and mentor junior researchers and students.
• Contribute to scientific publications and presentations at international conferences.

Skills

Molecular biology

Genomics

Genome editing

Stem cell biology

In vivo models

Next-generation sequencing

High-throughput screening

Scientific publishing

English communication

Education

PhD in molecular biology, biomedical sciences, genetics, cancer biology, or related discipline

Tools

CRISPR

NGS workflows

Job description

The Boettcher Lab, led by Prof. Dr. med. Steffen Boettcher, is seeking a highly motivated and talented Postdoctoral Researcher to join our team at the Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, affiliated with the Comprehensive Cancer Center Zurich (CCCZ). Our laboratory investigates fundamental molecular mechanisms of normal and malignant hematopoiesis, with a particular focus on hematopoietic stem cell biology, clonal hematopoiesis, and leukemogenesis. We combine cutting-edge molecular and cellular technologies, functional genomics, and preclinical disease models to address biologically and clinically relevant questions. The successful candidate will take a leading role in an innovative research project investigating molecular mechanisms of hematopoietic stem cell dysfunction, with the long-term goal of identifying novel therapeutic opportunities for patients with inherited bone marrow failure. Das Universitätsspital Zürich ist eines der grössten Spitäler in der Schweiz. Unsere über 8'600 Mitarbeitenden und rund 700 Auszubildende setzen sich täglich für das Wohl unserer Patient:innen ein.

Your responsibilities

• Independently design, coordinate, and perform experimental research projects.
• Establish and characterize advanced in vitro and in vivo disease models.
• Develop and apply CRISPR-based genome editing and functional genomics approaches.
• Conduct mechanistic investigations using molecular and cellular techniques.
• Analyze and interpret complex experimental datasets.
• Supervise and mentor junior researchers and students.
• Contribute to scientific publications and presentations at international conferences.

Your profile

• PhD in molecular biology, biomedical sciences, genetics, cancer biology, or a related discipline.
• Strong experimental background in molecular and cellular biology.
• Experience in genome editing, functional genomics, or stem cell biology is highly desirable.
• Experience with preclinical models, next-generation sequencing, or high-throughput screening is an advantage.
• A strong publication record appropriate to career stage.
• Scientific curiosity, creativity, independence, and excellent organizational skills.
• Excellent communication skills and fluency in English.

Unsere Benefits

• A fully funded position for 3 - 4 years, with salary and employment conditions in accordance with the guidelines of the Swiss National Science Foundation (SNSF).
• An exciting research project at the interface of basic and translational hematology.
• A stimulating, collaborative, and international scientific environment within the Boettcher Lab, Department of Medical Oncology and Hematology at the University Hospital Zurich / University of Zurich, and the Comprehensive Cancer Center Zurich (CCCZ).
• Access to state-of-the-art technologies and research infrastructure.
• Opportunities for scientific independence, professional development, and career advancement.
• Close collaboration with experienced scientists and clinician-researchers.
• Opportunities to publish in leading scientific journals and present at international conferences.

Über das USZ

Das Universitätsspital Zürich ist eines der grössten Spitäler in der Schweiz. Unsere über 8'600 Mitarbeitenden und rund 700 Auszubildende setzen sich täglich für das Wohl unserer Patient:innen ein.