Postdoctoral Researcher - Experimental Hematology and Functional Genomics 80-100%

Universitätsspital Zürich USZ; Zürich; On-site; CHF 90,000 - 110,000; Full time

Benefits offered by this job

Fully funded position for 3-4 years

Job summary

Universitätsspital Zürich USZ invites applications for a Postdoctoral Researcher to lead an innovative project on hematopoietic stem cell dysfunction, bridging basic science and translational hematology. You will design experiments, develop disease models, and apply genome editing to uncover mechanisms with therapeutic potential, collaborating across an international center.

The position is fully funded for 3-4 years in a stimulating, multidisciplinary environment at the University Hospital

Qualifications

• PhD in molecular biology, biomedical sciences, genetics, cancer biology, or related discipline.
• Strong background in molecular and cellular biology with a publication record.
• Experience in genome editing, functional genomics, or stem cell biology is highly desirable.
• Experience with preclinical models, sequencing, or high-throughput screening is an advantage.
• Excellent scientific communication and independence.

Responsibilities

• Independently design, coordinate, and perform experimental research projects.
• Establish and characterize advanced in vitro and in vivo disease models.
• Develop and apply CRISPR-based genome editing and functional genomics approaches.
• Conduct mechanistic investigations using molecular and cellular techniques.
• Analyze and interpret complex experimental datasets.
• Supervise and mentor junior researchers and students.
• Contribute to publications and presentations at international conferences.

Skills

Molecular biology

Genome editing (CRISPR)

Functional genomics

Stem cell biology

Data analysis

Preclinical models

In vivo experimentation

Education

PhD in molecular biology or related

Tools

CRISPR

Next-generation sequencing

Job description

The Boettcher Lab, led by Prof. Dr. med. Steffen Boettcher, is seeking a highly motivated and talented Postdoctoral Researcher to join our team at the Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, affiliated with the Comprehensive Cancer Center Zurich (CCCZ).

Our laboratory investigates fundamental molecular mechanisms of normal and malignant hematopoiesis, with a particular focus on hematopoietic stem cell biology, clonal hematopoiesis, and leukemogenesis. We combine cutting-edge molecular and cellular technologies, functional genomics, and preclinical disease models to address biologically and clinically relevant questions.

The successful candidate will take a leading role in an innovative research project investigating molecular mechanisms of hematopoietic stem cell dysfunction, with the long-term goal of identifying novel therapeutic opportunities for patients with inherited bone marrow failure.

Your responsibilities

• Independently design, coordinate, and perform experimental research projects.
• Establish and characterize advanced in vitro and in vivo disease models.
• Develop and apply CRISPR-based genome editing and functional genomics approaches.
• Conduct mechanistic investigations using molecular and cellular techniques.
• Analyze and interpret complex experimental datasets.
• Supervise and mentor junior researchers and students.
• Contribute to scientific publications and presentations at international conferences.

Your profile

• PhD in molecular biology, biomedical sciences, genetics, cancer biology, or a related discipline.
• Strong experimental background in molecular and cellular biology.
• Experience in genome editing, functional genomics, or stem cell biology is highly desirable.
• Experience with preclinical models, next-generation sequencing, or high-throughput screening is an advantage.
• A strong publication record appropriate to career stage.
• Scientific curiosity, creativity, independence, and excellent organizational skills.
• Excellent communication skills and fluency in English.

We offer

• A fully funded position for 3 - 4 years, with salary and employment conditions in accordance with the guidelines of the Swiss National Science Foundation (SNSF).
• An exciting research project at the interface of basic and translational hematology.
• A stimulating, collaborative, and international scientific environment within the Boettcher Lab, Department of Medical Oncology and Hematology at the University Hospital Zurich / University of Zurich, and the Comprehensive Cancer Center Zurich (CCCZ).
• Access to state-of-the-art technologies and research infrastructure.
• Opportunities for scientific independence, professional development, and career advancement.
• Close collaboration with experienced scientists and clinician-researchers.
• Opportunities to publish in leading scientific journals and present at international conferences.

Principal Investigator: Prof. Dr. med. Steffen Boettcher

Lab website: https://www.boettcherlab.com/

Unsere Benefits

Kita vor Ort

In unseren hauseigenen Kindertagesstätten werden deine Kinder liebevoll betreut. Lange Öffnungszeiten ohne Betriebsferien und subventionierte Betreuungsplätze entlasten dich im Alltag.

Gesundheit

Wir unterstützen deine Gesundheit. Neben persönlichen Beratungen und Kursen unseres Gesundheitsmanagements, die dein Wohlbefinden fördern, bieten wir dir mit einem subventionierten Jahresabonnement beim ASVZ Zugang zu über 120 Sportarten.

Flexibilität

Wir fördern eine ausgewogene Work-Life-Balance: Knapp die Hälfte unserer Mitarbeitenden arbeitet Teilzeit, und etwa 50% der Aufgaben lassen sich im Homeoffice erledigen - wenn es dein Berufsalltag zulässt.

Familienfreundlichkeit

Wir helfen dir, Familie und Beruf zu vereinbaren. Mütter haben Anspruch auf mindestens 6 Monate Mutterschaftsurlaub (davon 16 Wochen mit vollem Lohn), Väter auf mindestens 2 Monate Vaterschaftsurlaub (davon 2 Wochen mit vollem Lohn).

Weiterbildung & Entwicklung

Wir begleiten dich auf deinem beruflichen Weg und unterstützen deine Entwicklung mit individuellen Karriere- und Weiterbildungsmöglichkeiten.

Versicherungen

Wir übernehmen 60% deiner Pensionskassenbeiträge und bieten attraktive Sonderkonditionen für Ergänzungsversicherungen.

Mobilität

Du profitierst von einem persönlichen ZVV-BonusPass zum Spezialpreis oder erhältst einen fixen Geldbetrag für ein Generalabonnement (GA) oder Halbtax PLUS.

Telefonie

Du und deine Familienangehörigen profitieren von Sonderkonditionen für private Mobil-Abonnements.