Postdoctoral Researcher - Experimental Hematology and Functional Genomics 80-100%

USZ; Zürich; On-site; CHF 95,000 - 125,000; Full time

Benefits offered by this job

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Job summary

The Boettcher Lab at University Hospital Zurich and the University of Zurich seeks a highly motivated Postdoctoral Researcher to study molecular mechanisms of hematopoietic stem cell biology and leukemogenesis.

You will design and execute experiments, develop in vitro and in vivo disease models, and apply CRISPR-based genome editing and functional genomics to uncover therapeutic opportunities for inherited bone marrow failure. English communication essential.

Qualifications

• PhD in molecular biology, biomedical sciences, genetics, cancer biology, or a related field.
• Strong experimental background in molecular and cellular biology.
• Experience in genome editing, functional genomics, or stem cell biology is highly desirable.
• Experience with preclinical models, next-generation sequencing, or high-throughput screening is an advantage.
• A strong publication record appropriate to career stage.
• Fluency in English and excellent communication skills.

Responsibilities

• Independently design, coordinate, and perform experimental research projects.
• Establish and characterize advanced in vitro and in vivo disease models.
• Develop and apply CRISPR-based genome editing and functional genomics approaches.
• Conduct mechanistic investigations using molecular and cellular techniques.
• Analyze and interpret complex experimental datasets.
• Supervise and mentor junior researchers and students.
• Contribute to scientific publications and presentations at international conferences.

Skills

Molecular biology

Cell biology

Genome editing

Functional genomics

Stem cell biology

Preclinical models

Next-generation sequencing

High-throughput screening

Publications

English communication

Education

PhD in molecular biology, biomedical sciences, genetics, cancer biology, or related discipline

Tools

CRISPR

CRISPR-based genome editing

Job description

The Boettcher Lab, led by Prof. Dr. med. Steffen Boettcher, is seeking a highly motivated and talented Postdoctoral Researcher to join our team at the Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, affiliated with the Comprehensive Cancer Center Zurich (CCCZ).
Our laboratory investigates fundamental molecular mechanisms of normal and malignant hematopoiesis, with a particular focus on hematopoietic stem cell biology, clonal hematopoiesis, and leukemogenesis. We combine cutting‑edge molecular and cellular technologies, functional genomics, and preclinical disease models to address biologically and clinically relevant questions.
The successful candidate will take a leading role in an innovative research project investigating molecular mechanisms of hematopoietic stem cell dysfunction, with the long‑term goal of identifying novel therapeutic opportunities for patients with inherited bone marrow failure.

Your responsibilities

• Independently design, coordinate, and perform experimental research projects.
• Establish and characterize advanced in vitro and in vivo disease models.
• Develop and apply CRISPR‑based genome editing and functional genomics approaches.
• Conduct mechanistic investigations using molecular and cellular techniques.
• Analyze and interpret complex experimental datasets.
• Supervise and mentor junior researchers and students.
• Contribute to scientific publications and presentations at international conferences.

Your profile

• PhD in molecular biology, biomedical sciences, genetics, cancer biology, or a related discipline.
• Strong experimental background in molecular and cellular biology.
• Experience in genome editing, functional genomics, or stem cell biology is highly desirable.
• Experience with preclinical models, next‑generation sequencing, or high‑throughput screening is an advantage.
• A strong publication record appropriate to career stage.
• Scientific curiosity, creativity, independence, and excellent organizational skills.
• Excellent communication skills and fluency in English.

Application

Principal Investigator: Prof. Dr. med. Steffen Boettcher
Lab website: https://www.boettcherlab.com/

We look forward to receiving your application!

Für diese Stelle können keine Dossiers von Personalvermittlern berücksichtigt werden. Danke für Ihr Verständnis.

Unsere Benefits

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Über das USZ

Das Universitätsspital Zürich ist eines der grössten Spitäler in der Schweiz. Unsere über 8'600 Mitarbeitenden und rund 700 Auszubildende setzen sich täglich für das Wohl unserer Patient:innen ein.