Postdoc: Time-Resolved Room-Temp Crystallography

Paul Scherrer Institut

Villigen

On-site

CHF 90,000 - 120,000

Full time

13 days ago

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Job summary

Paul Scherrer Institut invites applications for a Postdoctoral Fellow in Time-resolved and Room-temperature Crystallography. The role focuses on developing cryo2RT approaches for dynamic structural biology using MX beamlines and cutting-edge detectors.

The candidate will work in a multidisciplinary team at a premier Swiss research facility and participate in international collaborations. The position involves implementing time-resolved experiments, establishing SSX workflows, and publishing

Qualifications

PhD in a relevant field.
Hands-on macromolecular crystallography experience.
Experience in serial/time-resolved crystallography at synchrotrons or XFELs.
Strong interest in method/instrumentation development; team collaboration.
Very good written and spoken English.
Desirable: protein production or crystallisation experience; reaction initiation (mixing, laser pump-probe, T-jump) or enzyme kinetics.
Desirable: Python programming; experience with serial data-processing software or radiation-damage studies.

Responsibilities

Implement and run time-resolved experiments with picolitre injector and microsecond pump–probe setup.
Apply methods to dynamic structural enzymology to capture intermediates.
Establish SSX workflows on cryo-compatible fixed-target chips for dynamic studies.
Characterize X-ray-induced heating and radiation damage at room temperature on micro- to millisecond scales; derive data-collection protocols.
Publish results and present at international conferences; support external users and collaborators.